Claudia Cristina Palos1,2, Beatriz Ferreira Timm3, Denise de Souza Paulo4, Cesar Eduardo Fernandes4, Ricardo Peres de Souto3, Emerson Oliveira4. 1. Department of Urogynecology and Vaginal Surgery within the Discipline of Gynecology at the ABC Medical School, Santo André, SP, Brazil. claupalos@hotmail.com. 2. , São Paulo, Brazil. claupalos@hotmail.com. 3. Department of Morphology and Physiology at the ABC Medical School, Santo André, SP, Brazil. 4. Department of Urogynecology and Vaginal Surgery within the Discipline of Gynecology at the ABC Medical School, Santo André, SP, Brazil.
Abstract
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism -1997 G/T with genital prolapse in Brazilian women. METHODS: A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the -1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein's coding sequence. RESULTS: No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse. CONCLUSIONS: Our study could not find any association between the -1997G/T polymorphism and genital prolapse in Brazilian women.
INTRODUCTION AND HYPOTHESIS: Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism -1997 G/T with genital prolapse in Brazilian women. METHODS: A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the -1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein's coding sequence. RESULTS: No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or ≥ 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse. CONCLUSIONS: Our study could not find any association between the -1997G/T polymorphism and genital prolapse in Brazilian women.
Entities:
Keywords:
Collagen I A1 gene; Pelvic organ prolapse; Polymorphism; rs1107946; −1997G/T
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