PURPOSE: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. MATERIALS AND METHODS: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of (18)F-fluorodeoxyglucose ((18)F-FDG) 37 MBq and (18)F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. RESULTS: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of (18)F-FDG was identified in the Harderian glands and striatum. High uptake of (18)F-NaF was found in the skull base and vault. CONCLUSIONS: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.
PURPOSE: We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain. MATERIALS AND METHODS: The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of (18)F-fluorodeoxyglucose ((18)F-FDG) 37 MBq and (18)F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI. RESULTS: Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of (18)F-FDG was identified in the Harderian glands and striatum. High uptake of (18)F-NaF was found in the skull base and vault. CONCLUSIONS: The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.
Authors: Bernd J Pichler; Martin S Judenhofer; Ciprian Catana; Jeffrey H Walton; Manfred Kneilling; Robert E Nutt; Stefan B Siegel; Claus D Claussen; Simon R Cherry Journal: J Nucl Med Date: 2006-04 Impact factor: 10.057
Authors: Martin S Judenhofer; Ciprian Catana; Brian K Swann; Stefan B Siegel; Wulf-Ingo Jung; Robert E Nutt; Simon R Cherry; Claus D Claussen; Bernd J Pichler Journal: Radiology Date: 2007-09 Impact factor: 11.105
Authors: Raymond R Raylman; Stan Majewski; Susan K Lemieux; S Sendhil Velan; Brian Kross; Vladimir Popov; Mark F Smith; Andrew G Weisenberger; Carl Zorn; Gary D Marano Journal: Phys Med Biol Date: 2006-11-23 Impact factor: 3.609
Authors: T Beyer; D W Townsend; T Brun; P E Kinahan; M Charron; R Roddy; J Jerin; J Young; L Byars; R Nutt Journal: J Nucl Med Date: 2000-08 Impact factor: 10.057