Literature DB >> 19596869

Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes.

María Belén Jiménez-Díaz1, Teresa Mulet, Sara Viera, Vanessa Gómez, Helen Garuti, Javier Ibáñez, Angela Alvarez-Doval, Leonard D Shultz, Antonio Martínez, Domingo Gargallo-Viola, Iñigo Angulo-Barturen.   

Abstract

Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2Rgamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc1.

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Year:  2009        PMID： 19596869      PMCID： PMC2764183          DOI： 10.1128/AAC.00519-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  11 in total

Review 1.  Humanized mice in translational biomedical research.

Authors:  Leonard D Shultz; Fumihiko Ishikawa; Dale L Greiner
Journal:  Nat Rev Immunol       Date:  2007-02       Impact factor: 53.106

2.  Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.

Authors:  S W Christianson; D L Greiner; R A Hesselton; J H Leif; E J Wagar; I B Schweitzer; T V Rajan; B Gott; D C Roopenian; L D Shultz
Journal:  J Immunol       Date:  1997-04-15       Impact factor: 5.422

3.  The course of infections and pathology in immunomodulated NOD/LtSz-SCID mice inoculated with Plasmodium falciparum laboratory lines and clinical isolates.

Authors:  Alicia Moreno; Elizabeth Ferrer; Susana Arahuetes; Cesar Eguiluz; Nico Van Rooijen; Agustin Benito
Journal:  Int J Parasitol       Date:  2005-11-28       Impact factor: 3.981

4.  Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells.

Authors:  Leonard D Shultz; Bonnie L Lyons; Lisa M Burzenski; Bruce Gott; Xiaohua Chen; Stanley Chaleff; Malak Kotb; Stephen D Gillies; Marie King; Julie Mangada; Dale L Greiner; Rupert Handgretinger
Journal:  J Immunol       Date:  2005-05-15       Impact factor: 5.422

5.  Selection of a trioxaquine as an antimalarial drug candidate.

Authors:  Frédéric Coslédan; Laurent Fraisse; Alain Pellet; François Guillou; Benjamin Mordmüller; Peter G Kremsner; Alicia Moreno; Dominique Mazier; Jean-Pierre Maffrand; Bernard Meunier
Journal:  Proc Natl Acad Sci U S A       Date:  2008-11-05       Impact factor: 11.205

6.  Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence.

Authors:  María Belén Jiménez-Díaz; Teresa Mulet; Vanesa Gómez; Sara Viera; Angela Alvarez; Helena Garuti; Yolanda Vázquez; Alejandra Fernández; Javier Ibáñez; Magdalena Jiménez; Domingo Gargallo-Viola; Iñigo Angulo-Barturen
Journal:  Cytometry A       Date:  2009-03       Impact factor: 4.355

Review 7.  Humanized SCID mouse models for biomedical research.

Authors:  T Pearson; D L Greiner; L D Shultz
Journal:  Curr Top Microbiol Immunol       Date:  2008       Impact factor: 4.291

8.  Synthesis and structure-activity relationships of 4-pyridones as potential antimalarials.

Authors:  Clive L Yeates; John F Batchelor; Edward C Capon; Neil J Cheesman; Mitch Fry; Alan T Hudson; Mary Pudney; Helen Trimming; James Woolven; José M Bueno; Jesús Chicharro; Esther Fernández; José M Fiandor; Domingo Gargallo-Viola; Federico Gómez de las Heras; Esperanza Herreros; María L León
Journal:  J Med Chem       Date:  2008-04-09       Impact factor: 7.446

9.  Cross-talk with myeloid accessory cells regulates human natural killer cell interferon-gamma responses to malaria.

Authors:  Kirsty C Newman; Daniel S Korbel; Julius C Hafalla; Eleanor M Riley
Journal:  PLoS Pathog       Date:  2006-12       Impact factor: 6.823

10.  A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes.

Authors:  Iñigo Angulo-Barturen; María Belén Jiménez-Díaz; Teresa Mulet; Joaquín Rullas; Esperanza Herreros; Santiago Ferrer; Elena Jiménez; Alfonso Mendoza; Javier Regadera; Philip J Rosenthal; Ian Bathurst; David L Pompliano; Federico Gómez de las Heras; Domingo Gargallo-Viola
Journal:  PLoS One       Date:  2008-05-21       Impact factor: 3.240
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  88 in total

1.  The NOD-scid IL2rγnull Mouse Model Is Suitable for the Study of Osteoarticular Brucellosis and Vaccine Safety.

Authors:  Omar H Khalaf; Sankar P Chaki; Daniel G Garcia-Gonzalez; Thomas A Ficht; Angela M Arenas-Gamboa
Journal:  Infect Immun       Date:  2019-05-21       Impact factor: 3.441

Review 2.  Host specificity of bacterial pathogens.

Authors:  Andreas Bäumler; Ferric C Fang
Journal:  Cold Spring Harb Perspect Med       Date:  2013-12-01       Impact factor: 6.915

3.  UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.

Authors:  Christel Brunschwig; Nina Lawrence; Dale Taylor; Efrem Abay; Mathew Njoroge; Gregory S Basarab; Claire Le Manach; Tanya Paquet; Diego Gonzàlez Cabrera; Aloysius T Nchinda; Carmen de Kock; Lubbe Wiesner; Paolo Denti; David Waterson; Benjamin Blasco; Didier Leroy; Michael J Witty; Cristina Donini; James Duffy; Sergio Wittlin; Karen L White; Susan A Charman; Maria Belén Jiménez-Díaz; Iñigo Angulo-Barturen; Esperanza Herreros; Francisco Javier Gamo; Rosemary Rochford; Dalu Mancama; Theresa L Coetzer; Mariëtte E van der Watt; Janette Reader; Lyn-Marie Birkholtz; Kennan C Marsh; Suresh M Solapure; John E Burke; Jacob A McPhail; Manu Vanaerschot; David A Fidock; Paul V Fish; Peter Siegl; Dennis A Smith; Grennady Wirjanata; Rintis Noviyanti; Ric N Price; Jutta Marfurt; Kigbafori D Silue; Leslie J Street; Kelly Chibale
Journal:  Antimicrob Agents Chemother       Date:  2018-08-27       Impact factor: 5.191

4.  A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria.

Authors:  Margaret A Phillips; Karen L White; Sreekanth Kokkonda; Xiaoyi Deng; John White; Farah El Mazouni; Kennan Marsh; Diana R Tomchick; Krishne Manjalanagara; Kakali Rani Rudra; Grennady Wirjanata; Rintis Noviyanti; Ric N Price; Jutta Marfurt; David M Shackleford; Francis C K Chiu; Michael Campbell; Maria Belen Jimenez-Diaz; Santiago Ferrer Bazaga; Iñigo Angulo-Barturen; Maria Santos Martinez; Maria Lafuente-Monasterio; Werner Kaminsky; Kigbafori Silue; Anne-Marie Zeeman; Clemens Kocken; Didier Leroy; Benjamin Blasco; Emilie Rossignol; Thomas Rueckle; Dave Matthews; Jeremy N Burrows; David Waterson; Michael J Palmer; Pradipsinh K Rathod; Susan A Charman
Journal:  ACS Infect Dis       Date:  2016-10-04       Impact factor: 5.084

Review 5.  Humanized mice for immune system investigation: progress, promise and challenges.

Authors:  Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Journal:  Nat Rev Immunol       Date:  2012-10-12       Impact factor: 53.106

6.  Evaluation of 4-Amino 2-Anilinoquinazolines against Plasmodium and Other Apicomplexan Parasites In Vitro and in a P. falciparum Humanized NOD-scid IL2Rγnull Mouse Model of Malaria.

Authors:  Paul R Gilson; William Nguyen; William A Poole; Jose E Teixeira; Jennifer K Thompson; Kaiyuan Guo; Rebecca J Stewart; Trent D Ashton; Karen L White; Laura M Sanz; Francisco-Javier Gamo; Susan A Charman; Sergio Wittlin; James Duffy; Christopher J Tonkin; Wai-Hong Tham; Brendan S Crabb; Brian M Cooke; Christopher D Huston; Alan F Cowman; Brad E Sleebs
Journal:  Antimicrob Agents Chemother       Date:  2019-02-26       Impact factor: 5.191

Review 7.  Antimalarial drug discovery - approaches and progress towards new medicines.

Authors:  Erika L Flannery; Arnab K Chatterjee; Elizabeth A Winzeler
Journal:  Nat Rev Microbiol       Date:  2013-11-11       Impact factor: 60.633

8.  Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria.

Authors:  Sreekanth Kokkonda; Xiaoyi Deng; Karen L White; Farah El Mazouni; John White; David M Shackleford; Kasiram Katneni; Francis C K Chiu; Helena Barker; Jenna McLaren; Elly Crighton; Gong Chen; Inigo Angulo-Barturen; Maria Belen Jimenez-Diaz; Santiago Ferrer; Leticia Huertas-Valentin; Maria Santos Martinez-Martinez; Maria Jose Lafuente-Monasterio; Rajesh Chittimalla; Shatrughan P Shahi; Sergio Wittlin; David Waterson; Jeremy N Burrows; Dave Matthews; Diana Tomchick; Pradipsinh K Rathod; Michael J Palmer; Susan A Charman; Margaret A Phillips
Journal:  J Med Chem       Date:  2020-04-16       Impact factor: 7.446

9.  Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Authors:  Nobutaka Kato; Eamon Comer; Tomoyo Sakata-Kato; Arvind Sharma; Manmohan Sharma; Micah Maetani; Jessica Bastien; Nicolas M Brancucci; Joshua A Bittker; Victoria Corey; David Clarke; Emily R Derbyshire; Gillian L Dornan; Sandra Duffy; Sean Eckley; Maurice A Itoe; Karin M J Koolen; Timothy A Lewis; Ping S Lui; Amanda K Lukens; Emily Lund; Sandra March; Elamaran Meibalan; Bennett C Meier; Jacob A McPhail; Branko Mitasev; Eli L Moss; Morgane Sayes; Yvonne Van Gessel; Mathias J Wawer; Takashi Yoshinaga; Anne-Marie Zeeman; Vicky M Avery; Sangeeta N Bhatia; John E Burke; Flaminia Catteruccia; Jon C Clardy; Paul A Clemons; Koen J Dechering; Jeremy R Duvall; Michael A Foley; Fabian Gusovsky; Clemens H M Kocken; Matthias Marti; Marshall L Morningstar; Benito Munoz; Daniel E Neafsey; Amit Sharma; Elizabeth A Winzeler; Dyann F Wirth; Christina A Scherer; Stuart L Schreiber
Journal:  Nature       Date:  2016-09-07       Impact factor: 49.962

10.  Hit-to-Lead Studies for the Antimalarial Tetrahydroisoquinolone Carboxanilides.

Authors:  David M Floyd; Philip Stein; Zheng Wang; Jian Liu; Steve Castro; Julie A Clark; Michele Connelly; Fangyi Zhu; Gloria Holbrook; Amy Matheny; Martina S Sigal; Jaeki Min; Rajkumar Dhinakaran; Senthil Krishnan; Sridevi Bashyum; Spencer Knapp; R Kiplin Guy
Journal:  J Med Chem       Date:  2016-08-25       Impact factor: 7.446
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