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Literature DB >> 195865

Isolation and characterization of MMS-sensitive mutants of Saccharomyces cerevisiae.

Abstract

We have isolated mutants sensitive to methyl methanesulfonate (MMS) in Saccharomyces cerevisiae. Alleles of rad1, rad4, rad52, rad55 and rad57 were found amoung these mms mutants. Twenty-nine of the mms mutants which complement the existing radiation-sensitive (rad and rev) mutants belong to 22 new complementation groups. Mutants from five complementation groups are sensitive only to MMS. Mutants of 11 complementation groups are sensitive to UV or X rays in addition to MMS, mutants of six complementation groups are sensitive to all three agents. The cross-sensitivities of these mms mutants to UV and X rays are discussed in terms of their possible involvement in DNA repair. Sporulation is reduced or absent in homozygous diploids of mms mutants from nine complementation groups.

Entities: Chemical Gene Species

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Year: 1977 PMID： 195865 PMCID： PMC1213670

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

20 in total

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Journal: Genetics Date: 1971-05 Impact factor: 4.562

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Authors: L Prakash
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102 in total

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Journal: Mol Cell Biol Date: 2000-06 Impact factor: 4.272

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Journal: Mol Cell Biol Date: 2013-02-04 Impact factor: 4.272

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