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Literature DB >> 1103845

SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis.

Abstract

A hypothesis was proposed several years ago that Escherichia coli posses an inducible DNA repair system ("SOS repair") which is also responsible for induced mutagenesis. Some characteristics of the SOS repair are (1) it is induced or activated following damage to DNA, (2) it requires do novo protein synthesis, (3) It requires several genetic functions of which the best-studied are recA+ and lex+ of E. coli, and (4) the physiological and genetic requirements for the expression of SOS repair are suspiciously similar to those necessary for the prophage induction. The SOS repair hypothesis has already served as the working hypothesis for many experiments, some of which are briefly reviewed. Also, some speculations are presented to stimulate further discussions and experimental tests.

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Year: 1975 PMID： 1103845 DOI： 10.1007/978-1-4684-2895-7_48

Source DB: PubMed Journal: Basic Life Sci ISSN： 0090-5542

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Cited

203 in total

1. The SOS response regulates adaptive mutation.

Authors: G J McKenzie; R S Harris; P L Lee; S M Rosenberg
Journal: Proc Natl Acad Sci U S A Date: 2000-06-06 Impact factor: 11.205

2. Assigning numbers to the arrows: parameterizing a gene regulation network by using accurate expression kinetics.

Authors: Michal Ronen; Revital Rosenberg; Boris I Shraiman; Uri Alon
Journal: Proc Natl Acad Sci U S A Date: 2002-07-26 Impact factor: 11.205

3. Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

Authors: Susan M Rosenberg; P J Hastings
Journal: J Bacteriol Date: 2004-08 Impact factor: 3.490

SOS repair hypothesis: phenomenology of an inducible DNA repair which is accompanied by mutagenesis.

1. The SOS response regulates adaptive mutation.

2. Assigning numbers to the arrows: parameterizing a gene regulation network by using accurate expression kinetics.

3. Adaptive point mutation and adaptive amplification pathways in the Escherichia coli Lac system: stress responses producing genetic change.

4. Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.

5. Defining the position of the switches between replicative and bypass DNA polymerases.

6. Suppression of tif-mediated induction of SOS functions in Escherichia coli by an altered dnaB protein.

7. Multidrug therapy and evolution of antibiotic resistance: when order matters.

Review 8. Nucleotide excision repair in humans.

9. Stress-Induced Mutagenesis: Implications in Cancer and Drug Resistance.

10. Genetic characterization of the inducible SOS-like system of Bacillus subtilis.