| Literature DB >> 19574348 |
Vincent J Munster1, Emmie de Wit, Judith M A van den Brand, Sander Herfst, Eefje J A Schrauwen, Theo M Bestebroer, David van de Vijver, Charles A Boucher, Marion Koopmans, Guus F Rimmelzwaan, Thijs Kuiken, Albert D M E Osterhaus, Ron A M Fouchier.
Abstract
The swine-origin A(H1N1) influenza virus that has emerged in humans in early 2009 has raised concerns about pandemic developments. In a ferret pathogenesis and transmission model, the 2009 A(H1N1) influenza virus was found to be more pathogenic than a seasonal A(H1N1) virus, with more extensive virus replication occurring in the respiratory tract. Replication of seasonal A(H1N1) virus was confined to the nasal cavity of ferrets, but the 2009 A(H1N1) influenza virus also replicated in the trachea, bronchi, and bronchioles. Virus shedding was more abundant from the upper respiratory tract for 2009 A(H1N1) influenza virus as compared with seasonal virus, and transmission via aerosol or respiratory droplets was equally efficient. These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences.Entities:
Mesh：
Year: 2009 PMID： 19574348 PMCID： PMC4814155 DOI： 10.1126/science.1177127
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728