| Literature DB >> 19465683 |
Rebecca J Garten1, C Todd Davis, Colin A Russell, Bo Shu, Stephen Lindstrom, Amanda Balish, Wendy M Sessions, Xiyan Xu, Eugene Skepner, Varough Deyde, Margaret Okomo-Adhiambo, Larisa Gubareva, John Barnes, Catherine B Smith, Shannon L Emery, Michael J Hillman, Pierre Rivailler, James Smagala, Miranda de Graaf, David F Burke, Ron A M Fouchier, Claudia Pappas, Celia M Alpuche-Aranda, Hugo López-Gatell, Hiram Olivera, Irma López, Christopher A Myers, Dennis Faix, Patrick J Blair, Cindy Yu, Kimberly M Keene, P David Dotson, David Boxrud, Anthony R Sambol, Syed H Abid, Kirsten St George, Tammy Bannerman, Amanda L Moore, David J Stringer, Patricia Blevins, Gail J Demmler-Harrison, Michele Ginsberg, Paula Kriner, Steve Waterman, Sandra Smole, Hugo F Guevara, Edward A Belongia, Patricia A Clark, Sara T Beatrice, Ruben Donis, Jacqueline Katz, Lyn Finelli, Carolyn B Bridges, Michael Shaw, Daniel B Jernigan, Timothy M Uyeki, Derek J Smith, Alexander I Klimov, Nancy J Cox.
Abstract
Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).Entities:
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Year: 2009 PMID： 19465683 PMCID： PMC3250984 DOI： 10.1126/science.1176225
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728