Literature DB >> 17289560

Chemical genetics: where genetics and pharmacology meet.

Zachary A Knight1, Kevan M Shokat.   

Abstract

Genetics and pharmacology can elicit surprisingly different phenotypes despite targeting the same protein. This Essay explores these unexpected differences and their implications for biology and medicine.

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Year:  2007        PMID： 17289560     DOI： 10.1016/j.cell.2007.01.021

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  102 in total

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2.  Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity.

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3.  Chemical genetics: reshaping biology through chemistry.

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4.  Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome.

Authors:  Xiaochen Liu; Gloria Michelle Ducasa; Shamroop Kumar Mallela; Jin-Ju Kim; Judith Molina; Alla Mitrofanova; Sydney Symone Wilbon; Mengyuan Ge; Antonio Fontanella; Christopher Pedigo; Javier Varona Santos; Robert G Nelson; Yelena Drexler; Gabriel Contreras; Hassan Al-Ali; Sandra Merscher; Alessia Fornoni
Journal:  Kidney Int       Date:  2020-07-30       Impact factor: 10.612

5.  Piceatannol Reduces Fat Accumulation in Caenorhabditis elegans.

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Journal:  J Med Food       Date:  2017-05-17       Impact factor: 2.786

Review 6.  Chemical genomics for studying parasite gene function and interaction.

Authors:  Jian Li; Jing Yuan; Ken Chih-Chien Cheng; James Inglese; Xin-zhuan Su
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Review 7.  The Bump-and-Hole Tactic: Expanding the Scope of Chemical Genetics.

Authors:  Kabirul Islam
Journal:  Cell Chem Biol       Date:  2018-08-02       Impact factor: 8.116

8.  A chemical genomics study identifies Snf1 as a repressor of GCN4 translation.

Authors:  Margaret K Shirra; Rhonda R McCartney; Chao Zhang; Kevan M Shokat; Martin C Schmidt; Karen M Arndt
Journal:  J Biol Chem       Date:  2008-10-27       Impact factor: 5.157

9.  Distinct expression patterns and roles of aldehyde dehydrogenases in normal oral mucosa keratinocytes: differential inhibitory effects of a pharmacological inhibitor and RNAi-mediated knockdown on cellular phenotype and epithelial morphology.

Authors:  Hiroko Kato; Kenji Izumi; Taro Saito; Hisashi Ohnuki; Michiko Terada; Yoshiro Kawano; Kayoko Nozawa-Inoue; Chikara Saito; Takeyasu Maeda
Journal:  Histochem Cell Biol       Date:  2012-12-19       Impact factor: 4.304

10.  The chemokine receptor antagonist, TAK-779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell function.

Authors:  Jia Ni; Yi-Na Zhu; Xiang-Gen Zhong; Yu Ding; Li-Fei Hou; Xian-Kun Tong; Wei Tang; Shiro Ono; Yi-Fu Yang; Jian-Ping Zuo
Journal:  Br J Pharmacol       Date:  2009-12       Impact factor: 8.739
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