| Literature DB >> 19490904 |
Abstract
To meet the continuous demand for energy, organisms use diverse signals to match food intake with energy needs. This paper reviews the effect of satiation signals and adiposity signals on food intake, including how they interact in the brain and how their influence changes with experience. Whereas meal initiation is influenced by external environmental factors, meal size is influenced by an array of signals that can be partitioned according to their reliability in indicating caloric content of food. It is argued that the malleability of satiation signals renders them poor candidates as pharmacological targets to control body weight.Entities:
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Year: 2009 PMID： 19490904 PMCID： PMC3090647 DOI： 10.1016/j.cmet.2009.04.007
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287