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Literature DB >> 19474079

Opportunities for microfluidic technologies in synthetic biology.

Shelly Gulati¹, Vincent Rouilly, Xize Niu, James Chappell, Richard I Kitney, Joshua B Edel, Paul S Freemont, Andrew J deMello.

Abstract

We introduce microfluidics technologies as a key foundational technology for synthetic biology experimentation. Recent advances in the field of microfluidics are reviewed and the potential of such a technological platform to support the rapid development of synthetic biology solutions is discussed.

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Year: 2009 PMID： 19474079 PMCID： PMC2843966 DOI： 10.1098/rsif.2009.0083.focus

Source DB: PubMed Journal: J R Soc Interface ISSN： 1742-5662 Impact factor: 4.118

70 in total

1. A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time.

Authors: Cory J Gerdts; David E Sharoyan; Rustem F Ismagilov
Journal: J Am Chem Soc Date: 2004-05-26 Impact factor: 15.419

2. Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system.

Authors: Ilya Shestopalov; Joshua D Tice; Rustem F Ismagilov
Journal: Lab Chip Date: 2004-07-05 Impact factor: 6.799

3. Microfluidic synthesis of colloidal silica.

Authors: Saif A Khan; Axel Günther; Martin A Schmidt; Klavs F Jensen
Journal: Langmuir Date: 2004-09-28 Impact factor: 3.882

4. Droplet formation in a microchannel network.

Authors: Takasi Nisisako; Toru Torii; Toshiro Higuchi
Journal: Lab Chip Date: 2002-01-18 Impact factor: 6.799

5. Geometrically mediated breakup of drops in microfluidic devices.

Authors: D R Link; S L Anna; D A Weitz; H A Stone
Journal: Phys Rev Lett Date: 2004-02-06 Impact factor: 9.161

6. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition.

Authors: Shengqing Xu; Zhihong Nie; Minseok Seo; Patrick Lewis; Eugenia Kumacheva; Howard A Stone; Piotr Garstecki; Douglas B Weibel; Irina Gitlin; George M Whitesides
Journal: Angew Chem Int Ed Engl Date: 2005-01-21 Impact factor: 15.336

7. Synthetic biology.

Authors: A Michael Sismour; Steven A Benner
Journal: Expert Opin Biol Ther Date: 2005-11 Impact factor: 4.388

Review 8. Unconventional detection methods for microfluidic devices.

Authors: Pertti J Viskari; James P Landers
Journal: Electrophoresis Date: 2006-05 Impact factor: 3.535

9. Cell-free protein expression in a microchannel array with passive pumping.

Authors: Ruba Khnouf; David J Beebe; Z Hugh Fan
Journal: Lab Chip Date: 2008-10-22 Impact factor: 6.799

Review 10. Engineered gene circuits.

Authors: Jeff Hasty; David McMillen; J J Collins
Journal: Nature Date: 2002-11-14 Impact factor: 49.962

20 in total

Opportunities for microfluidic technologies in synthetic biology.

1. A synthetic reaction network: chemical amplification using nonequilibrium autocatalytic reactions coupled in time.

2. Multi-step synthesis of nanoparticles performed on millisecond time scale in a microfluidic droplet-based system.

3. Microfluidic synthesis of colloidal silica.

4. Droplet formation in a microchannel network.

5. Geometrically mediated breakup of drops in microfluidic devices.

6. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition.

7. Synthetic biology.

Review 8. Unconventional detection methods for microfluidic devices.

9. Cell-free protein expression in a microchannel array with passive pumping.

Review 10. Engineered gene circuits.

1. Mesoscopic simulation of single DNA dynamics in rotational flows.

2. Synthetic biology: history, challenges and prospects.

3. Multi-dimensional studies of synthetic genetic promoters enabled by microfluidic impact printing.

4. Open-source, community-driven microfluidics with Metafluidics.

Review 5. Droplet-based microfluidics for artificial cell generation: a brief review.

Review 6. Revisiting lab-on-a-chip technology for drug discovery.

7. BioNetCAD: design, simulation and experimental validation of synthetic biochemical networks.

Review 8. Microfluidic technologies for synthetic biology.

9. Next-generation synthetic gene networks.

10. Validation of an entirely in vitro approach for rapid prototyping of DNA regulatory elements for synthetic biology.