Literature DB >> 19470509

Efficacy of triazoles in a murine disseminated infection by Candida krusei.

Marçal Mariné1, F Javier Pastor, Carolina Serena, Josep Guarro.   

Abstract

We evaluated the efficacies of posaconazole and voriconazole in comparison with that of amphotericin B in a systemic murine infection by Candida krusei. Posaconazole at 50 mg/kg/day and voriconazole at 40 and 60 mg/kg/day prolonged survival and reduced the fungal tissue burden in the kidneys of mice similarly to amphotericin B at 1.5 mg/kg/day and liposomal amphotericin B at 10 mg/kg/day. None of the treatments tested completely resolved the infection.

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Year:  2009        PMID： 19470509      PMCID： PMC2715613          DOI： 10.1128/AAC.00293-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  22 in total

Review 1.  Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.

Authors:  M A Pfaller; D J Sheehan; J H Rex
Journal:  Clin Microbiol Rev       Date:  2004-04       Impact factor: 26.132

2.  Pharmacokinetics of SCH 56592, a new azole broad-spectrum antifungal agent, in mice, rats, rabbits, dogs, and cynomolgus monkeys.

Authors:  A A Nomeir; P Kumari; M J Hilbert; S Gupta; D Loebenberg; A Cacciapuoti; R Hare; G H Miller; C C Lin; M N Cayen
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

3.  Posaconazole efficacy in a murine disseminated infection caused by Paecilomyces lilacinus.

Authors:  M Mar Rodríguez; F Javier Pastor; Carolina Serena; Josep Guarro
Journal:  J Antimicrob Chemother       Date:  2008-12-02       Impact factor: 5.790

4.  Voriconazole salvage treatment of invasive candidiasis.

Authors:  L Ostrosky-Zeichner; A M L Oude Lashof; B J Kullberg; J H Rex
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2003-10-17       Impact factor: 3.267

5.  Candida krusei, a multidrug-resistant opportunistic fungal pathogen: geographic and temporal trends from the ARTEMIS DISK Antifungal Surveillance Program, 2001 to 2005.

Authors:  M A Pfaller; D J Diekema; D L Gibbs; V A Newell; E Nagy; S Dobiasova; M Rinaldi; R Barton; A Veselov
Journal:  J Clin Microbiol       Date:  2007-12-12       Impact factor: 5.948

6.  The disposition of voriconazole in mouse, rat, rabbit, guinea pig, dog, and human.

Authors:  S J Roffey; S Cole; P Comby; D Gibson; S G Jezequel; A N R Nedderman; D A Smith; D K Walker; N Wood
Journal:  Drug Metab Dispos       Date:  2003-06       Impact factor: 3.922

7.  Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.

Authors:  M Mar Rodríguez; Enrique Calvo; Carolina Serena; Marçal Mariné; F Javier Pastor; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2009-02-17       Impact factor: 5.191

8.  Efficacy of isavuconazole, voriconazole and fluconazole in temporarily neutropenic murine models of disseminated Candida tropicalis and Candida krusei.

Authors:  J Majithiya; A Sharp; A Parmar; D W Denning; P A Warn
Journal:  J Antimicrob Chemother       Date:  2008-11-13       Impact factor: 5.790

9.  Efficacy of liposomal amphotericin B in treatment of systemic murine fusariosis.

Authors:  Montserrat Ortoneda; Javier Capilla; Francisco J Pastor; Isabel Pujol; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2002-07       Impact factor: 5.191

10.  Activities of fluconazole and voriconazole against bloodstream isolates of Candida glabrata and Candida krusei: a 14-year study in a Spanish tertiary medical centre.

Authors:  Guillermo Quindós; Luis Octavio Sánchez-Vargas; María Villar-Vidal; Elena Eraso; Miriam Alkorta; José Luis Hernández-Almaraz
Journal:  Int J Antimicrob Agents       Date:  2007-12-03       Impact factor: 5.283
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  1 in total

1.  Experimental therapy with azoles against Candida guilliermondii.

Authors:  Marta Sanchis; Francisco Javier Pastor; Javier Capilla; Deanna A Sutton; Annette W Fothergill; Josep Guarro
Journal:  Antimicrob Agents Chemother       Date:  2014-07-21       Impact factor: 5.191
  1 in total

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