OBJECTIVES: We have compared the efficacy of posaconazole and amphotericin B in an experimental murine model of paecilomycosis. METHODS: Immunosuppressed mice were treated with posaconazole at 25, 50, 75 or 100 mg/kg/day orally, amphotericin B at 1.5 or 3 mg/kg/day intraperitoneally or liposomal amphotericin B at 5 mg/kg/day intravenously. Treatment began 1 day after infection and continued for 10 days post-infection. Two strains of Paecilomyces lilacinus were tested. RESULTS: Posaconazole at 50 mg/kg/day was the only treatment able to significantly reduce fungal loads in the spleens, kidneys and livers of the mice infected by each of the two strains. CONCLUSIONS: The results suggest that posaconazole may have a clinical role in the treatment of disseminated paecilomycosis.
OBJECTIVES: We have compared the efficacy of posaconazole and amphotericin B in an experimental murine model of paecilomycosis. METHODS: Immunosuppressed mice were treated with posaconazole at 25, 50, 75 or 100 mg/kg/day orally, amphotericin B at 1.5 or 3 mg/kg/day intraperitoneally or liposomal amphotericin B at 5 mg/kg/day intravenously. Treatment began 1 day after infection and continued for 10 days post-infection. Two strains of Paecilomyces lilacinus were tested. RESULTS:Posaconazole at 50 mg/kg/day was the only treatment able to significantly reduce fungal loads in the spleens, kidneys and livers of the mice infected by each of the two strains. CONCLUSIONS: The results suggest that posaconazole may have a clinical role in the treatment of disseminated paecilomycosis.
Authors: Hanane Benbarkat; Karima Addetia; Amir H Salehi; Donald Sheppard; Thao Huynh Journal: Can J Infect Dis Med Microbiol Date: 2012 Impact factor: 2.471
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