| Literature DB >> 12069988 |
Montserrat Ortoneda1, Javier Capilla, Francisco J Pastor, Isabel Pujol, Josep Guarro.
Abstract
We have compared the activities of liposomal amphotericin B (LAMB) at 3, 5, 10, and 20 mg/kg/day and amphotericin B deoxycholate (AMB) at 1.5 and 2.5 mg/kg/day in a murine systemic infection by Fusarium verticillioides. Survival was improved by all treatments except AMB at 1.5 mg/kg/day. The tissue burden in liver was reduced by LAMB at all dosages and by AMB at 2.5 mg/kg/day. The two highest dosages of LAMB showed significant reductions in the spleen.Entities:
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Year: 2002 PMID: 12069988 PMCID: PMC127282 DOI: 10.1128/AAC.46.7.2273-2275.2002
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191