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Literature DB >> 19223617

Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.

M Mar Rodríguez¹, Enrique Calvo, Carolina Serena, Marçal Mariné, F Javier Pastor, Josep Guarro.

Abstract

We have evaluated the efficacies of micafungin, amphotericin B, and voriconazole, alone and in double and triple combinations, in a murine model of systemic infection by Scedosporium prolificans. Micafungin combined with voriconazole or amphotericin B was the most effective, these being the only treatments able to prolong survival and to reduce the fungal load in the kidneys and brain. Triple combinations of these drugs did not improve the results obtained with double combinations.

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Year: 2009 PMID： 19223617 PMCID： PMC2681574 DOI： 10.1128/AAC.01477-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

Review 1. Combination antifungal therapy.

Authors: Melissa D Johnson; Conan MacDougall; Luis Ostrosky-Zeichner; John R Perfect; John H Rex
Journal: Antimicrob Agents Chemother Date: 2004-03 Impact factor: 5.191

2. In vitro activities of new and conventional antifungal agents against clinical Scedosporium isolates.

Authors: Joseph Meletiadis; Jacques F G M Meis; Johan W Mouton; Juan Luis Rodriquez-Tudela; J Peter Donnelly; Paul E Verweij
Journal: Antimicrob Agents Chemother Date: 2002-01 Impact factor: 5.191

3. Disseminated infection by Scedosporium prolificans: an emerging fatality among haematology patients. Case report and review.

Authors: J Maertens; K Lagrou; H Deweerdt; I Surmont; G E Verhoef; J Verhaegen; M A Boogaerts
Journal: Ann Hematol Date: 2000-06 Impact factor: 3.673

Review 4. Emerging fungal pathogens: evolving challenges to immunocompromised patients for the twenty-first century.

Authors: T J Walsh; A H Groll
Journal: Transpl Infect Dis Date: 1999-12 Impact factor: 2.228

5. Liposomal amphotericin B and granulocyte colony-stimulating factor therapy in a murine model of invasive infection by Scedosporium prolificans.

Authors: Montserrat Ortoneda; Javier Capilla; Isabel Pujol; F Javier Pastor; Emilio Mayayo; Joan Fernández-Ballart; Josep Guarro
Journal: J Antimicrob Chemother Date: 2002-03 Impact factor: 5.790

6. Interaction of granulocyte colony-stimulating factor and high doses of liposomal amphotericin B in the treatment of systemic murine scedosporiosis.

Authors: Montserrat Ortoneda; Javier Capilla; F Javier Pastor; Carolina Serena; Josep Guarro
Journal: Diagn Microbiol Infect Dis Date: 2004-12 Impact factor: 2.803

Review 7. Disseminated infection and colonization by Scedosporium prolificans: a review of 18 cases, 1990-1999.

Authors: P Idigoras; E Pérez-Trallero; L Piñeiro; J Larruskain; M C López-Lopategui; N Rodríguez; J M González
Journal: Clin Infect Dis Date: 2001-05-04 Impact factor: 9.079

8. Efficacy of albaconazole (UR-9825) in treatment of disseminated Scedosporium prolificans infection in rabbits.

Authors: Javier Capilla; Clara Yustes; Emili Mayayo; Belkys Fernández; Montserrat Ortoneda; F Javier Pastor; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2003-06 Impact factor: 5.191

Review 9. Epidemiology and outcome of Scedosporium prolificans infection, a review of 162 cases.

Authors: Juan Luis Rodriguez-Tudela; Juan Berenguer; Josep Guarro; A Serda Kantarcioglu; Regine Horre; G Sybren de Hoog; Manuel Cuenca-Estrella
Journal: Med Mycol Date: 2009-06 Impact factor: 4.076

10. In vitro evaluation of double and triple combinations of antifungal drugs against Aspergillus fumigatus and Aspergillus terreus.

Authors: Eric Dannaoui; Olivier Lortholary; Françoise Dromer
Journal: Antimicrob Agents Chemother Date: 2004-03 Impact factor: 5.191

17 in total

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Journal: Virulence Date: 2015-03-09 Impact factor: 5.882

2. MIC values of voriconazole are predictive of treatment results in murine infections by Aspergillus terreus species complex.

Authors: Valentina Salas; F Javier Pastor; Deanna A Sutton; Enrique Calvo; Emilio Mayayo; Annette W Fothergill; Michael G Rinaldi; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2013-01-07 Impact factor: 5.191

3. Evaluation of the in vitro activity of voriconazole as predictive of in vivo outcome in a murine Aspergillus fumigatus infection model.

Authors: Valentina Salas; F Javier Pastor; Enrique Calvo; Deanna A Sutton; Annette W Fothergill; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2013-01-07 Impact factor: 5.191

4. Species-specific antifungal susceptibility patterns of Scedosporium and Pseudallescheria species.

Authors: Michaela Lackner; G Sybren de Hoog; Paul E Verweij; Mohammad J Najafzadeh; Ilse Curfs-Breuker; Corné H Klaassen; Jacques F Meis
Journal: Antimicrob Agents Chemother Date: 2012-01-30 Impact factor: 5.191

5. Experimental therapy with azoles against Candida guilliermondii.

Authors: Marta Sanchis; Francisco Javier Pastor; Javier Capilla; Deanna A Sutton; Annette W Fothergill; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2014-07-21 Impact factor: 5.191

6. In vitro activity and in vivo efficacy of posaconazole in treatment of murine infections by different isolates of the Aspergillus terreus complex.

Authors: Valentina Salas; F Javier Pastor; M M Rodríguez; Enrique Calvo; Emilio Mayayo; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2010-11-29 Impact factor: 5.191

7. Correlation of in vitro activity, serum levels, and in vivo efficacy of posaconazole against Rhizopus microsporus in a murine disseminated infection.

Authors: M Mar Rodríguez; F Javier Pastor; Enrique Calvo; Valentina Salas; Deanna A Sutton; Josep Guarro
Journal: Antimicrob Agents Chemother Date: 2009-09-28 Impact factor: 5.191