Literature DB >> 19450461

On the function of pentameric phospholamban: ion channel or storage form?

Lucia Becucci, Alessandro Cembran, Christine B Karim, David D Thomas, Rolando Guidelli, Jiali Gao, Gianluigi Veglia.   

Abstract

Phospholamban (PLN) is an integral membrane protein that inhibits the sarcoplasmic reticulum Ca(2+)-ATPase, thereby regulating muscle contractility. We report a combined electrochemical and theoretical study demonstrating that the pentameric PLN does not possess channel activity for conducting chloride or calcium ions across the lipid membrane. This suggests that the pentameric configuration of PLN primarily serves as a storage form for the regulatory function of muscle relaxation by the PLN monomer.

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Year:  2009        PMID： 19450461      PMCID： PMC2712152          DOI： 10.1016/j.bpj.2009.03.013

Source DB:  PubMed          Journal:  Biophys J        ISSN： 0006-3495            Impact factor:   4.033


  24 in total

1.  Helical structure of phospholamban in membrane bilayers.

Authors:  S O Smith; T Kawakami; W Liu; M Ziliox; S Aimoto
Journal:  J Mol Biol       Date:  2001-11-09       Impact factor: 5.469

2.  Phospholamban pentamer quaternary conformation determined by in-gel fluorescence anisotropy.

Authors:  Seth L Robia; Nicole C Flohr; David D Thomas
Journal:  Biochemistry       Date:  2005-03-22       Impact factor: 3.162

3.  The structure of phospholamban pentamer reveals a channel-like architecture in membranes.

Authors:  Kirill Oxenoid; James J Chou
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-25       Impact factor: 11.205

4.  Molecular dynamics studies on structure and dynamics of phospholamban monomer and pentamer in membranes.

Authors:  Taehoon Kim; Jinhyuk Lee; Wonpil Im
Journal:  Proteins       Date:  2009-07

Review 5.  Structural perspectives of phospholamban, a helical transmembrane pentamer.

Authors:  I T Arkin; P D Adams; A T Brünger; S O Smith; D M Engelman
Journal:  Annu Rev Biophys Biomol Struct       Date:  1997

6.  Phospholamban forms Ca2+-selective channels in lipid bilayers.

Authors:  R J Kovacs; M T Nelson; H K Simmerman; L R Jones
Journal:  J Biol Chem       Date:  1988-12-05       Impact factor: 5.157

7.  Depolymerization of phospholamban in the presence of calcium pump: a fluorescence energy transfer study.

Authors:  L G Reddy; L R Jones; D D Thomas
Journal:  Biochemistry       Date:  1999-03-30       Impact factor: 3.162

8.  Channels formed by the transmembrane helix of phospholamban: a simulation study.

Authors:  M S Sansom; G R Smith; O S Smart; S O Smith
Journal:  Biophys Chem       Date:  1997-12-01       Impact factor: 2.352

9.  A leucine zipper stabilizes the pentameric membrane domain of phospholamban and forms a coiled-coil pore structure.

Authors:  H K Simmerman; Y M Kobayashi; J M Autry; L R Jones
Journal:  J Biol Chem       Date:  1996-03-08       Impact factor: 5.157

10.  The influence of geometry, surface character, and flexibility on the permeation of ions and water through biological pores.

Authors:  Oliver Beckstein; Mark S P Sansom
Journal:  Phys Biol       Date:  2004-06       Impact factor: 2.583
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  14 in total

1.  Structural dynamics and topology of phosphorylated phospholamban homopentamer reveal its role in the regulation of calcium transport.

Authors:  Vitaly V Vostrikov; Kaustubh R Mote; Raffaello Verardi; Gianluigi Veglia
Journal:  Structure       Date:  2013-10-24       Impact factor: 5.006

2.  Oligomeric interactions of sarcolipin and the Ca-ATPase.

Authors:  Joseph M Autry; John E Rubin; Sean D Pietrini; Deborah L Winters; Seth L Robia; David D Thomas
Journal:  J Biol Chem       Date:  2011-07-07       Impact factor: 5.157

Review 3.  Modeling and simulation of ion channels.

Authors:  Christopher Maffeo; Swati Bhattacharya; Jejoong Yoo; David Wells; Aleksei Aksimentiev
Journal:  Chem Rev       Date:  2012-10-04       Impact factor: 60.622

4.  The Phospholamban Pentamer Alters Function of the Sarcoplasmic Reticulum Calcium Pump SERCA.

Authors:  John Paul Glaves; Joseph O Primeau; L Michel Espinoza-Fonseca; M Joanne Lemieux; Howard S Young
Journal:  Biophys J       Date:  2019-01-22       Impact factor: 4.033

5.  Structural dynamics and conformational equilibria of SERCA regulatory proteins in membranes by solid-state NMR restrained simulations.

Authors:  Alfonso De Simone; Kaustubh R Mote; Gianluigi Veglia
Journal:  Biophys J       Date:  2014-06-17       Impact factor: 4.033

6.  Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method.

Authors:  Raffaello Verardi; Lei Shi; Nathaniel J Traaseth; Naomi Walsh; Gianluigi Veglia
Journal:  Proc Natl Acad Sci U S A       Date:  2011-05-16       Impact factor: 11.205

7.  Phosphorylation and mutation of phospholamban alter physical interactions with the sarcoplasmic reticulum calcium pump.

Authors:  John Paul Glaves; Catharine A Trieber; Delaine K Ceholski; David L Stokes; Howard S Young
Journal:  J Mol Biol       Date:  2010-11-23       Impact factor: 5.469

Review 8.  Perturbations of Native Membrane Protein Structure in Alkyl Phosphocholine Detergents: A Critical Assessment of NMR and Biophysical Studies.

Authors:  Christophe Chipot; François Dehez; Jason R Schnell; Nicole Zitzmann; Eva Pebay-Peyroula; Laurent J Catoire; Bruno Miroux; Edmund R S Kunji; Gianluigi Veglia; Timothy A Cross; Paul Schanda
Journal:  Chem Rev       Date:  2018-02-28       Impact factor: 60.622

9.  The role of sarcolipin and ATP in the transport of phosphate ion into the sarcoplasmic reticulum.

Authors:  Lucia Becucci; Rolando Guidelli; Christine B Karim; David D Thomas; Gianluigi Veglia
Journal:  Biophys J       Date:  2009-11-18       Impact factor: 4.033

10.  Structures of the excited states of phospholamban and shifts in their populations upon phosphorylation.

Authors:  Alfonso De Simone; Martin Gustavsson; Rinaldo W Montalvao; Lei Shi; Gianluigi Veglia; Michele Vendruscolo
Journal:  Biochemistry       Date:  2013-09-11       Impact factor: 3.162
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