| Literature DB >> 17823352 |
Christina A Cuomo1, Ulrich Güldener, Jin-Rong Xu, Frances Trail, B Gillian Turgeon, Antonio Di Pietro, Jonathan D Walton, Li-Jun Ma, Scott E Baker, Martijn Rep, Gerhard Adam, John Antoniw, Thomas Baldwin, Sarah Calvo, Yueh-Long Chang, David Decaprio, Liane R Gale, Sante Gnerre, Rubella S Goswami, Kim Hammond-Kosack, Linda J Harris, Karen Hilburn, John C Kennell, Scott Kroken, Jon K Magnuson, Gertrud Mannhaupt, Evan Mauceli, Hans-Werner Mewes, Rudolf Mitterbauer, Gary Muehlbauer, Martin Münsterkötter, David Nelson, Kerry O'donnell, Thérèse Ouellet, Weihong Qi, Hadi Quesneville, M Isabel G Roncero, Kye-Yong Seong, Igor V Tetko, Martin Urban, Cees Waalwijk, Todd J Ward, Jiqiang Yao, Bruce W Birren, H Corby Kistler.
Abstract
We sequenced and annotated the genome of the filamentous fungus Fusarium graminearum, a major pathogen of cultivated cereals. Very few repetitive sequences were detected, and the process of repeat-induced point mutation, in which duplicated sequences are subject to extensive mutation, may partially account for the reduced repeat content and apparent low number of paralogous (ancestrally duplicated) genes. A second strain of F. graminearum contained more than 10,000 single-nucleotide polymorphisms, which were frequently located near telomeres and within other discrete chromosomal segments. Many highly polymorphic regions contained sets of genes implicated in plant-fungus interactions and were unusually divergent, with higher rates of recombination. These regions of genome innovation may result from selection due to interactions of F. graminearum with its plant hosts.Entities:
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Year: 2007 PMID： 17823352 DOI： 10.1126/science.1143708
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728