Literature DB >> 19448636

Netting neutrophils in autoimmune small-vessel vasculitis.

Kai Kessenbrock1, Markus Krumbholz, Ulf Schönermarck, Walter Back, Wolfgang L Gross, Zena Werb, Hermann-Josef Gröne, Volker Brinkmann, Dieter E Jenne.   

Abstract

Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.

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Year:  2009        PMID： 19448636      PMCID： PMC2760083          DOI： 10.1038/nm.1959

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  16 in total

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Authors:  Volker Brinkmann; Ulrike Reichard; Christian Goosmann; Beatrix Fauler; Yvonne Uhlemann; David S Weiss; Yvette Weinrauch; Arturo Zychlinsky
Journal:  Science       Date:  2004-03-05       Impact factor: 47.728

2.  Myeloperoxidase: a myeloid cell nuclear antigen with DNA-binding properties.

Authors:  S Murao; F J Stevens; A Ito; E Huberman
Journal:  Proc Natl Acad Sci U S A       Date:  1988-02       Impact factor: 11.205

Review 3.  Small-vessel vasculitis.

Authors:  J C Jennette; R J Falk
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Journal:  J Pathol       Date:  2005-03       Impact factor: 7.996

5.  Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice.

Authors:  Hong Xiao; Peter Heeringa; Peiqi Hu; Zhi Liu; Minglang Zhao; Yasuaki Aratani; Nobuyo Maeda; Ronald J Falk; J Charles Jennette
Journal:  J Clin Invest       Date:  2002-10       Impact factor: 14.808

6.  Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages.

Authors:  L Harper; Y Ren; J Savill; D Adu; C O Savage
Journal:  Am J Pathol       Date:  2000-07       Impact factor: 4.307

7.  Anti-neutrophil cytoplasmic autoantibodies induce neutrophils to degranulate and produce oxygen radicals in vitro.

Authors:  R J Falk; R S Terrell; L A Charles; J C Jennette
Journal:  Proc Natl Acad Sci U S A       Date:  1990-06       Impact factor: 11.205

8.  Nucleosomal DNA fragments in autoimmune diseases.

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Journal:  Ann N Y Acad Sci       Date:  2006-09       Impact factor: 5.691

9.  Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors.

Authors:  Elizabeth A Leadbetter; Ian R Rifkin; Andreas M Hohlbaum; Britte C Beaudette; Mark J Shlomchik; Ann Marshak-Rothstein
Journal:  Nature       Date:  2002-04-11       Impact factor: 49.962

10.  Antineutrophil cytoplasmic autoantibodies against the murine homolog of proteinase 3 (Wegener autoantigen) are pathogenic in vivo.

Authors:  Heiko Pfister; Markus Ollert; Leopold F Fröhlich; Leticia Quintanilla-Martinez; Thomas V Colby; Ulrich Specks; Dieter E Jenne
Journal:  Blood       Date:  2004-05-18       Impact factor: 22.113
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Journal:  JCI Insight       Date:  2018-12-06

Review 2.  ANCA-associated vasculitides--advances in pathogenesis and treatment.

Authors:  Min Chen; Cees G M Kallenberg
Journal:  Nat Rev Rheumatol       Date:  2010-10-05       Impact factor: 20.543

3.  IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis.

Authors:  James M Kelley; Paul A Monach; Chuanyi Ji; Yebin Zhou; Jianming Wu; Sumiaki Tanaka; Alfred D Mahr; Sharleen Johnson; Carol McAlear; David Cuthbertson; Simon Carette; John C Davis; Paul F Dellaripa; Gary S Hoffman; Nader Khalidi; Carol A Langford; Phillip Seo; E William St Clair; Ulrich Specks; John H Stone; Robert F Spiera; Steven R Ytterberg; Peter A Merkel; Jeffrey C Edberg; Robert P Kimberly
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6.  Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

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Journal:  Nat Chem Biol       Date:  2010-12-19       Impact factor: 15.040

Review 7.  Neutrophil proteinase 3 and dipeptidyl peptidase I (cathepsin C) as pharmacological targets in granulomatosis with polyangiitis (Wegener granulomatosis).

Authors:  Brice Korkmaz; Adam Lesner; Stephanie Letast; Yassir K Mahdi; Marie-Lise Jourdan; Sandrine Dallet-Choisy; Sylvain Marchand-Adam; Christine Kellenberger; Marie-Claude Viaud-Massuard; Dieter E Jenne; Francis Gauthier
Journal:  Semin Immunopathol       Date:  2013-02-06       Impact factor: 9.623

Review 8.  B cell-mediated pathogenesis of ANCA-mediated vasculitis.

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Review 9.  Extracellular DNA and autoimmune diseases.

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Review 10.  Disentangling the role of neutrophil extracellular traps in rheumatic diseases.

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Journal:  Curr Opin Rheumatol       Date:  2017-01       Impact factor: 5.006
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