Yaíma L Lightfoot1, Mariana J Kaplan. 1. Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Abstract
PURPOSE OF REVIEW: A breakdown of immune tolerance to self-antigens in a genetically predisposing background, precipitated by environmental triggers, contributes to the development of systemic autoimmune diseases. Renewed interest in the immunomodulatory capabilities of neutrophils in systemic autoimmunity has identified neutrophil extracellular trap (NET) formation as a distinguishing action of neutrophils in afflicted hosts. RECENT FINDINGS: Oxidation of nucleic acids and posttranslational modifications of proteins distinctly occur during NET formation and may promote enhanced immunogenicity. Various autoantibodies, immune complexes, and other inflammatory stimuli have been recently reported to promote NET formation in individuals with autoimmune diseases. Associations between level of NETosis and adverse outcomes in systemic autoimmune diseases, including thrombosis, adverse pregnancy outcomes, and renal disease, continue to be investigated. SUMMARY: Understanding the putative pathogenic role and sequelae of NETosis in rheumatic diseases is a major focus of ongoing research efforts. Mechanisms elucidated by these discoveries may provide novel therapeutic targets to inhibit NET formation and/or promote the clearance of immunogenic NET material.
PURPOSE OF REVIEW: A breakdown of immune tolerance to self-antigens in a genetically predisposing background, precipitated by environmental triggers, contributes to the development of systemic autoimmune diseases. Renewed interest in the immunomodulatory capabilities of neutrophils in systemic autoimmunity has identified neutrophil extracellular trap (NET) formation as a distinguishing action of neutrophils in afflicted hosts. RECENT FINDINGS: Oxidation of nucleic acids and posttranslational modifications of proteins distinctly occur during NET formation and may promote enhanced immunogenicity. Various autoantibodies, immune complexes, and other inflammatory stimuli have been recently reported to promote NET formation in individuals with autoimmune diseases. Associations between level of NETosis and adverse outcomes in systemic autoimmune diseases, including thrombosis, adverse pregnancy outcomes, and renal disease, continue to be investigated. SUMMARY: Understanding the putative pathogenic role and sequelae of NETosis in rheumatic diseases is a major focus of ongoing research efforts. Mechanisms elucidated by these discoveries may provide novel therapeutic targets to inhibit NET formation and/or promote the clearance of immunogenic NET material.
Authors: Eneida Villanueva; Srilakshmi Yalavarthi; Celine C Berthier; Jeffrey B Hodgin; Ritika Khandpur; Andrew M Lin; Cory J Rubin; Wenpu Zhao; Stephen H Olsen; Matthew Klinker; David Shealy; Michael F Denny; Joel Plumas; Laurence Chaperot; Matthias Kretzler; Allen T Bruce; Mariana J Kaplan Journal: J Immunol Date: 2011-05-25 Impact factor: 5.422
Authors: Peter C Grayson; Carmelo Carmona-Rivera; Lijing Xu; Noha Lim; Zhong Gao; Adam L Asare; Ulrich Specks; John H Stone; Philip Seo; Robert F Spiera; Carol A Langford; Gary S Hoffman; Cees G M Kallenberg; E William St Clair; Nadia K Tchao; Steven R Ytterberg; Deborah J Phippard; Peter A Merkel; Mariana J Kaplan; Paul A Monach Journal: Arthritis Rheumatol Date: 2015-07 Impact factor: 10.995
Authors: Srilakshmi Yalavarthi; Travis J Gould; Ashish N Rao; Levi F Mazza; Alexandra E Morris; Carlos Núñez-Álvarez; Diego Hernández-Ramírez; Paula L Bockenstedt; Patricia C Liaw; Antonio R Cabral; Jason S Knight Journal: Arthritis Rheumatol Date: 2015-11 Impact factor: 10.995
Authors: Carlos A Cañas; Felipe Cañas; Fabio Bonilla-Abadía; Fabio E Ospina; Gabriel J Tobón Journal: Autoimmunity Date: 2015-09-15 Impact factor: 2.815
Authors: Vanja Sisirak; Benjamin Sally; Vivette D'Agati; Wilnelly Martinez-Ortiz; Z Birsin Özçakar; Joseph David; Ali Rashidfarrokhi; Ada Yeste; Casandra Panea; Asiya Seema Chida; Milena Bogunovic; Ivaylo I Ivanov; Francisco J Quintana; Inaki Sanz; Keith B Elkon; Mustafa Tekin; Fatoş Yalçınkaya; Timothy J Cardozo; Robert M Clancy; Jill P Buyon; Boris Reizis Journal: Cell Date: 2016-06-09 Impact factor: 41.582
Authors: Wendy Marder; Jason S Knight; Mariana J Kaplan; Emily C Somers; Xu Zhang; Alexander A O'Dell; Vasantha Padmanabhan; Richard W Lieberman Journal: Lupus Sci Med Date: 2016-04-27
Authors: Sebastian Boeltz; Poorya Amini; Hans-Joachim Anders; Felipe Andrade; Rostyslav Bilyy; Simon Chatfield; Iwona Cichon; Danielle M Clancy; Jyaysi Desai; Tetiana Dumych; Nishant Dwivedi; Rachael Ann Gordon; Jonas Hahn; Andrés Hidalgo; Markus H Hoffmann; Mariana J Kaplan; Jason S Knight; Elzbieta Kolaczkowska; Paul Kubes; Moritz Leppkes; Angelo A Manfredi; Seamus J Martin; Christian Maueröder; Norma Maugeri; Ioannis Mitroulis; Luis E Munoz; Daigo Nakazawa; Indira Neeli; Victor Nizet; Elmar Pieterse; Marko Z Radic; Christiane Reinwald; Konstantinos Ritis; Patrizia Rovere-Querini; Michal Santocki; Christine Schauer; Georg Schett; Mark Jay Shlomchik; Hans-Uwe Simon; Panagiotis Skendros; Darko Stojkov; Peter Vandenabeele; Tom Vanden Berghe; Johan van der Vlag; Ljubomir Vitkov; Maren von Köckritz-Blickwede; Shida Yousefi; Alexander Zarbock; Martin Herrmann Journal: Cell Death Differ Date: 2019-01-08 Impact factor: 15.828
Authors: Carmelo Carmona-Rivera; Sami S Khaznadar; Kyawt W Shwin; Jorge A Irizarry-Caro; Liam J O'Neil; Yudong Liu; Kenneth A Jacobson; Amanda K Ombrello; Deborah L Stone; Wanxia L Tsai; Daniel L Kastner; Ivona Aksentijevich; Mariana J Kaplan; Peter C Grayson Journal: Blood Date: 2019-04-23 Impact factor: 25.476