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Literature DB >> 29553134

Extracellular DNA and autoimmune diseases.

Abstract

Extracellular DNA is secreted from various sources including apoptotic cells, NETotic neutrophils and bacterial biofilms. Extracellular DNA can stimulate innate immune responses to induce type-I IFN production after being endocytosed. This process is central in antiviral responses but it also plays important role in the pathogenesis of a range of autoimmune diseases such as systemic lupus erythematosus. We discuss the recent advances in the understanding of the role of extracellular DNA, released from apoptotic and NETotic cells, in autoimmunity.

Entities: Disease

Keywords: DNA; autoimmunity; type I IFN

Mesh：

Substances：

Year: 2018 PMID： 29553134 PMCID： PMC6141478 DOI： 10.1038/cmi.2017.136

Source DB: PubMed Journal: Cell Mol Immunol ISSN： 1672-7681 Impact factor: 11.530

123 in total

1. Inhibition of virus multiplication by foreign nucleic acid.

Authors: Z ROTEM; R A COX; A ISAACS
Journal: Nature Date: 1963-02-09 Impact factor: 49.962

2. Foreign nucleic acids as the stimulus to make interferon.

Authors: A ISAACS; R A COX; Z ROTEM
Journal: Lancet Date: 1963-07-20 Impact factor: 79.321

3. IFI16 is an innate immune sensor for intracellular DNA.

Authors: Leonie Unterholzner; Sinead E Keating; Marcin Baran; Kristy A Horan; Søren B Jensen; Shruti Sharma; Cherilyn M Sirois; Tengchuan Jin; Eicke Latz; T Sam Xiao; Katherine A Fitzgerald; Søren R Paludan; Andrew G Bowie
Journal: Nat Immunol Date: 2010-10-03 Impact factor: 25.606

4. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

Authors: Gregory M Barton; Jonathan C Kagan; Ruslan Medzhitov
Journal: Nat Immunol Date: 2005-12-11 Impact factor: 25.606

Review 5. Apoptosis genes and autoimmunity.

Authors: D L Vaux; R A Flavell
Journal: Curr Opin Immunol Date: 2000-12 Impact factor: 7.486

6. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.

Authors: M Botto; C Dell'Agnola; A E Bygrave; E M Thompson; H T Cook; F Petry; M Loos; P P Pandolfi; M J Walport
Journal: Nat Genet Date: 1998-05 Impact factor: 38.330

7. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells.

Authors: Taeil Kim; Shwetha Pazhoor; Musheng Bao; Zhiqiang Zhang; Shino Hanabuchi; Valeria Facchinetti; Laura Bover; Joel Plumas; Laurence Chaperot; Jun Qin; Yong-Jun Liu
Journal: Proc Natl Acad Sci U S A Date: 2010-08-09 Impact factor: 11.205

Review 8. Immune sensing of DNA.

Authors: Søren R Paludan; Andrew G Bowie
Journal: Immunity Date: 2013-05-23 Impact factor: 31.745

9. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus.

Authors: Richard Furie; Munther Khamashta; Joan T Merrill; Victoria P Werth; Kenneth Kalunian; Philip Brohawn; Gabor G Illei; Jorn Drappa; Liangwei Wang; Stephen Yoo
Journal: Arthritis Rheumatol Date: 2017-02 Impact factor: 10.995

10. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.

Authors: Vilma Urbonaviciute; Barbara G Fürnrohr; Silke Meister; Luis Munoz; Petra Heyder; Francesco De Marchis; Marco E Bianchi; Carsten Kirschning; Hermann Wagner; Angelo A Manfredi; Joachim R Kalden; Georg Schett; Patrizia Rovere-Querini; Martin Herrmann; Reinhard E Voll
Journal: J Exp Med Date: 2008-12-08 Impact factor: 14.307

17 in total

Extracellular DNA and autoimmune diseases.

1. Inhibition of virus multiplication by foreign nucleic acid.

2. Foreign nucleic acids as the stimulus to make interferon.

3. IFI16 is an innate immune sensor for intracellular DNA.

4. Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA.

Review 5. Apoptosis genes and autoimmunity.

6. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies.

7. Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells.

Review 8. Immune sensing of DNA.

9. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus.

10. Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.

Review 1. DNA-Based Biomaterials for Immunoengineering.

2. Extracellular vesicles package dsDNA to aggravate Crohn's disease by activating the STING pathway.

Review 3. Infectious Uveitis in Horses and New Insights in Its Leptospiral Biofilm-Related Pathogenesis.

Review 4. Extracellular vesicles and particles impact the systemic landscape of cancer.

Review 5. The Contribution of Neutrophils and NETs to the Development of Type 1 Diabetes.

Review 6. The role of extracellular DNA (exDNA) in cellular processes.

Review 7. Below the surface: The inner lives of TLR4 and TLR9.

Review 8. Self-DNA at the Epicenter of SLE: Immunogenic Forms, Regulation, and Effects.

Review 9. Circulating Mitochondrial DNA Stimulates Innate Immune Signaling Pathways to Mediate Acute Kidney Injury.

Review 10. Base Excision Repair in the Immune System: Small DNA Lesions With Big Consequences.