Literature DB >> 21170021

Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.

Abdul Hakkim1, Tobias A Fuchs, Nancy E Martinez, Simone Hess, Heino Prinz, Arturo Zychlinsky, Herbert Waldmann.   

Abstract

The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.

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Year:  2010        PMID： 21170021     DOI： 10.1038/nchembio.496

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  25 in total

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Review 3.  Neutrophils and immunity: challenges and opportunities.

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5.  Analysis of the eukaryotic prenylome by isoprenoid affinity tagging.

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6.  The neutrophil-activating protein of Helicobacter pylori (HP-NAP) activates the MAPK pathway in human neutrophils.

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8.  Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival.

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  245 in total

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7.  Lupus and proliferative nephritis are PAD4 independent in murine models.

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9.  Characterization of neutrophils and macrophages from ex vivo-cultured murine bone marrow for morphologic maturation and functional responses by imaging flow cytometry.

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Review 10.  Cancer and inflammation.

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