OBJECTIVE: To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS). DESIGN/PATIENTS/MEASUREMENTS: We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles. RESULTS: Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH. CONCLUSION: An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.
OBJECTIVE: To explore the relationship of insulin resistance (IR) and adipokines (leptin, adiponectin, RBP4) to anti-Mullerian hormone (AMH) levels in women without polycystic ovary syndrome (PCOS). DESIGN/PATIENTS/MEASUREMENTS: We recruited 120 healthy, reproductive age women without PCOS. An overnight fasting blood draw, anthropometric measurements, analyses of serum levels of AMH, adipokines (leptin, adiponectin and RBP4) and total testosterone, a homeostasis model assessment for insulin resistance (HOMA-IR) and a transvaginal ultrasound scan were performed between the third and fifth day of their spontaneous menstrual cycles. RESULTS: Higher HOMA-IR levels were associated with lower levels of AMH. After adjustment for age, serum AMH levels negatively correlated with insulin, fasting glucose, HOMA-IR and RBP4. However, a positive correlation was identified between serum AMH and adiponectin. A final multiple stepwise linear regression demonstrated that HOMA-IR was independently associated with AMH. CONCLUSION: An independent relationship exists between HOMA-IR and AMH in women without PCOS, possibly due to the effect of abnormal insulin action on AMH secretion by granulosa cells.
Authors: Lia A Bernardi; Mercedes R Carnethon; Peter J de Chavez; Deborah E Ikhena; Lisa M Neff; Donna D Baird; Erica E Marsh Journal: Obesity (Silver Spring) Date: 2016-12-07 Impact factor: 5.002
Authors: Zaher O Merhi; David B Seifer; Jeremy Weedon; Oluwatoyin Adeyemi; Susan Holman; Kathryn Anastos; Elizabeth T Golub; Mary Young; Roksana Karim; Ruth Greenblatt; Howard Minkoff Journal: Fertil Steril Date: 2012-04-10 Impact factor: 7.329
Authors: Maria E Bleil; Steven E Gregorich; Daniel McConnell; Mitchell P Rosen; Marcelle I Cedars Journal: Menopause Date: 2013-11 Impact factor: 2.953
Authors: Maria E Bleil; Steven E Gregorich; Nancy E Adler; Barbara Sternfeld; Mitchell P Rosen; Marcelle I Cedars Journal: Fertil Steril Date: 2013-10-29 Impact factor: 7.329