Double-volume 1H spectroscopy with interleaved acquisitions using tilted gradients.

A method is presented by which volume selective in vivo 1H spectra of two different voxels can be acquired in an interlaced mode using PRESS or STEAM spectroscopy. Spatially tilted gradients are employed for voxel definition so as to avoid mutual saturation. Independent volume selective shimming of the voxels is possible. Two spectra of volumes as small as (1.5 cm)3 can be acquired from human brain within 14 min even from very disadvantageous locations close to air-borne interfaces.