Georg Oeltzschner1,2, Nicolaas A J Puts1,2, Kimberly L Chan1,2,3, Vincent O Boer4, Peter B Barker1,2, Richard A E Edden1,2. 1. Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins University School of Medicine, Baltimore, MD, USA. 2. F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, USA. 3. Department of Biomedical Engineering, the Johns Hopkins University School of Medicine, Baltimore, MD, USA. 4. Hvidovre Hospital, Danish Research Center for Magnetic Resonance, Hvidovre, Denmark.
Abstract
PURPOSE: To develop J-difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ-aminobutyric acid (GABA) or glutathione. METHODS: PRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual-voxel MEGA-PRIAM (and compared with conventional single-voxel MEGA-PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants. RESULTS: MEGA-PRIAM effectively separated phantom spectra with ∼3-4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA- and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7-8 cm). MEGA-PRIAM experiments showed higher signal-to-noise ratio than sequential single-voxel experiments of the same total duration (mean improvement 1.38 ± 0.24). CONCLUSIONS: Simultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA-PRIAM increases data acquisition rates compared with MEGA-PRESS by a factor of 2. Magn Reson Med, 2016.
PURPOSE: To develop J-difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ-aminobutyric acid (GABA) or glutathione. METHODS: PRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual-voxel MEGA-PRIAM (and compared with conventional single-voxel MEGA-PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants. RESULTS: MEGA-PRIAM effectively separated phantom spectra with ∼3-4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA- and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7-8 cm). MEGA-PRIAM experiments showed higher signal-to-noise ratio than sequential single-voxel experiments of the same total duration (mean improvement 1.38 ± 0.24). CONCLUSIONS: Simultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA-PRIAM increases data acquisition rates compared with MEGA-PRESS by a factor of 2. Magn Reson Med, 2016.
Authors: Mark A Griswold; Peter M Jakob; Robin M Heidemann; Mathias Nittka; Vladimir Jellus; Jianmin Wang; Berthold Kiefer; Axel Haase Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Kimberly L Chan; Nicolaas A J Puts; Michael Schär; Peter B Barker; Richard A E Edden Journal: Magn Reson Med Date: 2016-04-19 Impact factor: 4.668
Authors: Richard A E Edden; Nicolaas A J Puts; Ashley D Harris; Peter B Barker; C John Evans Journal: J Magn Reson Imaging Date: 2013-11-13 Impact factor: 4.813
Authors: Ricardo C G Landim; Richard A E Edden; Bernd Foerster; Li Min Li; Roberto J M Covolan; Gabriela Castellano Journal: Magn Reson Imaging Date: 2015-12-02 Impact factor: 2.546
Authors: Jamie Near; Richard Edden; C John Evans; Raphaël Paquin; Ashley Harris; Peter Jezzard Journal: Magn Reson Med Date: 2014-01-16 Impact factor: 4.668
Authors: Mark Mikkelsen; Peter B Barker; Pallab K Bhattacharyya; Maiken K Brix; Pieter F Buur; Kim M Cecil; Kimberly L Chan; David Y-T Chen; Alexander R Craven; Koen Cuypers; Michael Dacko; Niall W Duncan; Ulrike Dydak; David A Edmondson; Gabriele Ende; Lars Ersland; Fei Gao; Ian Greenhouse; Ashley D Harris; Naying He; Stefanie Heba; Nigel Hoggard; Tun-Wei Hsu; Jacobus F A Jansen; Alayar Kangarlu; Thomas Lange; R Marc Lebel; Yan Li; Chien-Yuan E Lin; Jy-Kang Liou; Jiing-Feng Lirng; Feng Liu; Ruoyun Ma; Celine Maes; Marta Moreno-Ortega; Scott O Murray; Sean Noah; Ralph Noeske; Michael D Noseworthy; Georg Oeltzschner; James J Prisciandaro; Nicolaas A J Puts; Timothy P L Roberts; Markus Sack; Napapon Sailasuta; Muhammad G Saleh; Michael-Paul Schallmo; Nicholas Simard; Stephan P Swinnen; Martin Tegenthoff; Peter Truong; Guangbin Wang; Iain D Wilkinson; Hans-Jörg Wittsack; Hongmin Xu; Fuhua Yan; Chencheng Zhang; Vadim Zipunnikov; Helge J Zöllner; Richard A E Edden Journal: Neuroimage Date: 2017-07-14 Impact factor: 6.556
Authors: Yury Koush; Douglas L Rothman; Kevin L Behar; Robin A de Graaf; Fahmeed Hyder Journal: J Cereb Blood Flow Metab Date: 2022-01-26 Impact factor: 6.960
Authors: Lihong Tang; Yibo Zhao; Yudu Li; Rong Guo; Bryan Clifford; Georges El Fakhri; Chao Ma; Zhi-Pei Liang; Jie Luo Journal: Magn Reson Med Date: 2020-07-29 Impact factor: 4.668
Authors: Yury Koush; Robin A de Graaf; Ron Kupers; Laurence Dricot; Maurice Ptito; Kevin L Behar; Douglas L Rothman; Fahmeed Hyder Journal: J Cereb Blood Flow Metab Date: 2021-01-20 Impact factor: 6.200
Authors: Georg Oeltzschner; Kimberly L Chan; Muhammad G Saleh; Mark Mikkelsen; Nicolaas A Puts; Richard A E Edden Journal: NMR Biomed Date: 2017-10-26 Impact factor: 4.478
Authors: Nicolaas A J Puts; Stefanie Heba; Ashley D Harris; Christopher John Evans; David J McGonigle; Martin Tegenthoff; Tobias Schmidt-Wilcke; Richard A E Edden Journal: Biomedicines Date: 2018-07-24