Literature DB >> 19429480

Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment.

Amy M Dworkin1, Tim H-M Huang, Amanda Ewart Toland.   

Abstract

Epigenetic alterations of the genome such as DNA promoter methylation and chromatin remodeling play an important role in tumorigenesis. Recent findings indicate epigenetic modifications as key factors in breast carcinogenesis. These modifications are quite appealing as targets for preventative care and therapeutics because of their potential for reversal. Future medical care for breast cancer patients will likely depend upon a better understanding of the roles epigenetic modifications play in carcinogenesis. Here, we discuss the importance of epigenetics in breast cancer detection, prognosis, and therapy with an emphasis on mechanisms and epigenetic contributions to field cancerization effects.

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Year:  2009        PMID： 19429480      PMCID： PMC2734184          DOI： 10.1016/j.semcancer.2009.02.007

Source DB:  PubMed          Journal:  Semin Cancer Biol        ISSN： 1044-579X            Impact factor:   15.707


  56 in total

1.  Direct acetylation of the estrogen receptor alpha hinge region by p300 regulates transactivation and hormone sensitivity.

Authors:  C Wang; M Fu; R H Angeletti; L Siconolfi-Baez; A T Reutens; C Albanese; M P Lisanti; B S Katzenellenbogen; S Kato; T Hopp; S A Fuqua; G N Lopez; P J Kushner; R G Pestell
Journal:  J Biol Chem       Date:  2001-03-09       Impact factor: 5.157

2.  DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

Authors:  M Esteller; M F Fraga; M Guo; J Garcia-Foncillas; I Hedenfalk; A K Godwin; J Trojan; C Vaurs-Barrière; Y J Bignon; S Ramus; J Benitez; T Caldes; Y Akiyama; Y Yuasa; V Launonen; M J Canal; R Rodriguez; G Capella; M A Peinado; A Borg; L A Aaltonen; B A Ponder; S B Baylin; J G Herman
Journal:  Hum Mol Genet       Date:  2001-12-15       Impact factor: 6.150

3.  Dissecting complex epigenetic alterations in breast cancer using CpG island microarrays.

Authors:  P S Yan; C M Chen; H Shi; F Rahmatpanah; S H Wei; C W Caldwell; T H Huang
Journal:  Cancer Res       Date:  2001-12-01       Impact factor: 12.701

Review 4.  A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications.

Authors:  Boudewijn J M Braakhuis; Maarten P Tabor; J Alain Kummer; C René Leemans; Ruud H Brakenhoff
Journal:  Cancer Res       Date:  2003-04-15       Impact factor: 12.701

5.  Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

Authors:  P O Chappuis; L Kapusta; L R Bégin; N Wong; J S Brunet; S A Narod; J Slingerland; W D Foulkes
Journal:  J Clin Oncol       Date:  2000-12-15       Impact factor: 44.544

Review 6.  DNA methylation: an alternative pathway to cancer.

Authors:  S A Wajed; P W Laird; T R DeMeester
Journal:  Ann Surg       Date:  2001-07       Impact factor: 12.969

7.  Loss of heterozygosity analysis at the BRCA loci in tumor samples from patients with familial breast cancer.

Authors:  Ana Osorio; Miguel de la Hoya; Raquel Rodríguez-López; Angel Martínez-Ramírez; Alicia Cazorla; Juan José Granizo; Manel Esteller; Carmen Rivas; Trinidad Caldés; Javier Benítez
Journal:  Int J Cancer       Date:  2002-05-10       Impact factor: 7.396

8.  DNA methylation in serum of breast cancer patients: an independent prognostic marker.

Authors:  Hannes M Müller; Andreas Widschwendter; Heidi Fiegl; Lennart Ivarsson; Georg Goebel; Elisabeth Perkmann; Christian Marth; Martin Widschwendter
Journal:  Cancer Res       Date:  2003-11-15       Impact factor: 12.701

Review 9.  DNA methylation and breast carcinogenesis.

Authors:  Martin Widschwendter; Peter A Jones
Journal:  Oncogene       Date:  2002-08-12       Impact factor: 9.867

10.  Epigenetic silencing and deletion of the BRCA1 gene in sporadic breast cancer.

Authors:  Valgerdur Birgisdottir; Olafur A Stefansson; Sigridur K Bodvarsdottir; Holmfridur Hilmarsdottir; Jon G Jonasson; Jorunn E Eyfjord
Journal:  Breast Cancer Res       Date:  2006       Impact factor: 6.466
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  62 in total

1.  Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.

Authors:  Erika da Costa Prando; Luciane Regina Cavalli; Cláudia Aparecida Rainho
Journal:  Epigenetics       Date:  2011-12       Impact factor: 4.528

2.  Identification of 5 novel genes methylated in breast and other epithelial cancers.

Authors:  Victoria K Hill; Luke B Hesson; Temuujin Dansranjavin; Ashraf Dallol; Ivan Bieche; Sophie Vacher; Stella Tommasi; Timothy Dobbins; Dean Gentle; David Euhus; Cheryl Lewis; Reinhard Dammann; Robyn L Ward; John Minna; Eammon R Maher; Gerd P Pfeifer; Farida Latif
Journal:  Mol Cancer       Date:  2010-03-05       Impact factor: 27.401

3.  Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells.

Authors:  Yu-I Weng; Pei-Yin Hsu; Sandya Liyanarachchi; Joseph Liu; Daniel E Deatherage; Yi-Wen Huang; Tao Zuo; Benjamin Rodriguez; Ching-Hung Lin; Ann-Lii Cheng; Tim H-M Huang
Journal:  Toxicol Appl Pharmacol       Date:  2010-08-01       Impact factor: 4.219

4.  DNA methylation and breast tumor clinicopathological features: The Western New York Exposures and Breast Cancer (WEB) study.

Authors:  Catherine L Callahan; Youjin Wang; Catalin Marian; Daniel Y Weng; Kevin H Eng; Meng-Hua Tao; Christine B Ambrosone; Jing Nie; Maurizio Trevisan; Dominic Smiraglia; Stephen B Edge; Peter G Shields; Jo L Freudenheim
Journal:  Epigenetics       Date:  2016-05-31       Impact factor: 4.528

5.  Protein expression and methylation of MGMT, a DNA repair gene and their correlation with clinicopathological parameters in invasive ductal carcinoma of the breast.

Authors:  Asia Asiaf; Shiekh Tanveer Ahmad; Ajaz Ahmad Malik; Shiekh Aejaz Aziz; Zubaida Rasool; Akbar Masood; Mohammad Afzal Zargar
Journal:  Tumour Biol       Date:  2015-03-29

Review 6.  Artificial light at night: melatonin as a mediator between the environment and epigenome.

Authors:  Abraham Haim; Abed E Zubidat
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-05-05       Impact factor: 6.237

7.  Effects of In Utero Exposure to Ethinyl Estradiol on Tamoxifen Resistance and Breast Cancer Recurrence in a Preclinical Model.

Authors:  Leena Hilakivi-Clarke; Anni Wärri; Kerrie B Bouker; Xiyuan Zhang; Katherine L Cook; Lu Jin; Alan Zwart; Nguyen Nguyen; Rong Hu; M Idalia Cruz; Sonia de Assis; Xiao Wang; Jason Xuan; Yue Wang; Bryan Wehrenberg; Robert Clarke
Journal:  J Natl Cancer Inst       Date:  2016-09-08       Impact factor: 13.506

Review 8.  An evolutionary perspective on field cancerization.

Authors:  Kit Curtius; Nicholas A Wright; Trevor A Graham
Journal:  Nat Rev Cancer       Date:  2017-12-08       Impact factor: 60.716

Review 9.  Epigenetics: the link between nature and nurture.

Authors:  Stephanie A Tammen; Simonetta Friso; Sang-Woon Choi
Journal:  Mol Aspects Med       Date:  2012-08-10

10.  Molecular subtypes of breast cancer are associated with characteristic DNA methylation patterns.

Authors:  Karolina Holm; Cecilia Hegardt; Johan Staaf; Johan Vallon-Christersson; Göran Jönsson; Håkan Olsson; Ake Borg; Markus Ringnér
Journal:  Breast Cancer Res       Date:  2010-06-18       Impact factor: 6.466
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