OBJECTIVE: VarioGuide (BrainLAB AG, Feldkirchen, Germany) is a new system for frameless image-guided stereotaxy. In the present study, we aimed to assess target point accuracy in a laboratory setting and the clinical feasibility of the system. METHODS: Using the phantom of our frame-based stereotactic system (Riechert-Mundinger; Inomed Medizintechnik GmbH, Teningen, Germany), target points were approached from different angles with the frameless system. Target point deviation in the x, y, and z planes was assessed. Furthermore, patients harboring intracranial lesions were diagnostically biopsied using VarioGuide. RESULTS: Phantom-based accuracy measurements yielded a mean target point deviation of 0.7 mm. Between February 2007 and April 2008, 27 patients were diagnostically biopsied. Lesion volumes ranged from 0.2 to 117.6 cm3, trajectory length ranged from 25.3 to 64.1 mm, and the diagnostic yield was 93%. CONCLUSION: Concluding from the phantom measurements with ideal image-object registration, assumed spherical lesions with a volume of 0.524 cm can be biopsied with 100% target localization. Early clinical data revealed VarioGuide to be safe and accurate for lesions of 0.2 cm3 and larger. Thereby, the system seems feasible for the biopsy of most intracranial lesions.
OBJECTIVE: VarioGuide (BrainLAB AG, Feldkirchen, Germany) is a new system for frameless image-guided stereotaxy. In the present study, we aimed to assess target point accuracy in a laboratory setting and the clinical feasibility of the system. METHODS: Using the phantom of our frame-based stereotactic system (Riechert-Mundinger; Inomed Medizintechnik GmbH, Teningen, Germany), target points were approached from different angles with the frameless system. Target point deviation in the x, y, and z planes was assessed. Furthermore, patients harboring intracranial lesions were diagnostically biopsied using VarioGuide. RESULTS: Phantom-based accuracy measurements yielded a mean target point deviation of 0.7 mm. Between February 2007 and April 2008, 27 patients were diagnostically biopsied. Lesion volumes ranged from 0.2 to 117.6 cm3, trajectory length ranged from 25.3 to 64.1 mm, and the diagnostic yield was 93%. CONCLUSION: Concluding from the phantom measurements with ideal image-object registration, assumed spherical lesions with a volume of 0.524 cm can be biopsied with 100% target localization. Early clinical data revealed VarioGuide to be safe and accurate for lesions of 0.2 cm3 and larger. Thereby, the system seems feasible for the biopsy of most intracranial lesions.
Authors: Daniel L Cooke; Michael R Levitt; Louis J Kim; Danial K Hallam; Laligam N Sekhar; Basavaraj V Ghodke Journal: Int J Comput Assist Radiol Surg Date: 2015-08-05 Impact factor: 2.924
Authors: Marc C Mabray; Sanjit Datta; Prasheel V Lillaney; Teri Moore; Sonja Gehrisch; Jason F Talbott; Michael R Levitt; Basavaraj V Ghodke; Paul S Larson; Daniel L Cooke Journal: J Neurointerv Surg Date: 2015-06-05 Impact factor: 5.836
Authors: E D H Gates; J S Lin; J S Weinberg; S S Prabhu; J Hamilton; J D Hazle; G N Fuller; V Baladandayuthapani; D T Fuentes; D Schellingerhout Journal: AJNR Am J Neuroradiol Date: 2020-02-06 Impact factor: 3.825
Authors: Joshua D Bernstock; Zachary Wright; Asim K Bag; Florian Gessler; George Yancey Gillespie; James M Markert; Gregory K Friedman; James M Johnston Journal: World Neurosurg Date: 2018-11-24 Impact factor: 2.104
Authors: Ryan T Woodall; David A Hormuth Ii; Chengyue Wu; Michael R A Abdelmalik; William T Phillips; Ande Bao; Thomas J R Hughes; Andrew J Brenner; Thomas E Yankeelov Journal: Biomed Phys Eng Express Date: 2021-05-28
Authors: Iris S C Verploegh; Victor Volovici; Iain K Haitsma; Joost W Schouten; Clemens M Dirven; Johan M Kros; Ruben Dammers Journal: Acta Neurochir (Wien) Date: 2015-08-29 Impact factor: 2.216