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Literature DB >> 19398646

In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.

Kyriaki Kanellakopoulou¹, Periklis Panagopoulos, Efthymia Giannitsioti, Thomas Tsaganos, Dionyssia-Pinelopi Carrer, Nicolas Efstathopoulos, Evangelos J Giamarellos-Bourboulis.

Abstract

A synthetic crystallic semihydrate form of calcium sulfate, Stimulan, was evaluated as a biodegradable carrier for the daily in vitro elution of daptomycin. Daptomycin and Stimulan were admixed at a ratio of 95:5. Elution lasted for 28 days. Eluted concentrations peaked on days 1 and 11, when the mean values were 1,320.1 and 949.2 microg/ml, respectively. The lowest eluted concentration was detected on day 28. These results support the application of the system described in experimental models of osteomyelitis.

Entities: Chemical Disease

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Year: 2009 PMID： 19398646 PMCID： PMC2704707 DOI： 10.1128/AAC.01490-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

16 in total

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Authors: K Kanellakopoulou; N Galanakis; E J Giamarellos-Bourboulis; C Rifiotis; K Papakostas; A Andreopoulos; E Dounis; P Karagianakos; H Giamarellou
Journal: J Antimicrob Chemother Date: 2000-08 Impact factor: 5.790

2. Activities of daptomycin and comparative antimicrobials, singly and in combination, against extracellular and intracellular Staphylococcus aureus and its stable small-colony variant in human monocyte-derived macrophages and in broth.

Authors: Aldona L Baltch; William J Ritz; Lawrence H Bopp; Phyllis Michelsen; Raymond P Smith
Journal: Antimicrob Agents Chemother Date: 2008-03-10 Impact factor: 5.191

3. In vitro activity of daptomycin against Gram-positive cocci: the first multicentre study in Greece.

Authors: E Malli; I Spiliopoulou; F Kolonitsiou; D Klapsa; E Giannitsioti; K Pantelidi; A Pratti; M Panopoulou; S Grapsa; E Alepopoulou; I Neonakis; F Frantzidou; S Alexiou-Daniel; D Bakola; C Koutsia-Carouzou; H Malamou-Lada; L Zerva; E Vlahaki; S Kartali-Ktenidou; E D Anastassiou; E Petinaki
Journal: Int J Antimicrob Agents Date: 2008-09-05 Impact factor: 5.283

4. Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.

Authors: T A Wichelhaus; E Dingeldein; M Rauschmann; S Kluge; R Dieterich; V Schäfer; V Brade
Journal: J Antimicrob Chemother Date: 2001-07 Impact factor: 5.790

Review 5. Carrier systems for the local delivery of antibiotics in bone infections.

Authors: K Kanellakopoulou; E J Giamarellos-Bourboulis
Journal: Drugs Date: 2000-06 Impact factor: 9.546

Review 6. Daptomycin: rationale and role in the management of skin and soft tissue infections.

Authors: R A Seaton
Journal: J Antimicrob Chemother Date: 2008-11 Impact factor: 5.790

Review 7. Pre-clinical experience with daptomycin.

Authors: P M Hawkey
Journal: J Antimicrob Chemother Date: 2008-11 Impact factor: 5.790

8. In vitro elution of moxifloxacin and fusidic acid by a synthetic crystallic semihydrate form of calcium sulphate (Stimulan).

Authors: Periklis Panagopoulos; Thomas Tsaganos; Diamantis Plachouras; Dionyssia-Pinelopi Carrer; Antonios Papadopoulos; Helen Giamarellou; Kyriaki Kanellakopoulou
Journal: Int J Antimicrob Agents Date: 2008-09-13 Impact factor: 5.283

9. Local treatment of experimental Pseudomonas aeruginosa osteomyelitis with a biodegradable dilactide polymer releasing ciprofloxacin.

Authors: Kyriaki Kanellakopoulou; George C Thivaios; Maria Kolia; Ismini Dontas; Lydia Nakopoulou; Eleftherios Dounis; Evangelos J Giamarellos-Bourboulis; Andreas Andreopoulos; Panayotis Karagiannakos; Helen Giamarellou
Journal: Antimicrob Agents Chemother Date: 2008-04-14 Impact factor: 5.191

10. Daptomycin eluted from calcium sulfate appears effective against Staphylococcus.

Authors: Nathan D Webb; Jonathan D McCanless; Harry S Courtney; Joel D Bumgardner; Warren O Haggard
Journal: Clin Orthop Relat Res Date: 2008-04-23 Impact factor: 4.176

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Authors: Karen E Beenken; James K Smith; Robert A Skinner; Sandra G Mclaren; William Bellamy; M Johannes Gruenwald; Horace J Spencer; Jessica A Jennings; Warren O Haggard; Mark S Smeltzer
Journal: J Biomater Appl Date: 2014-05-21 Impact factor: 2.646

2. Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.

Authors: Sean S Aiken; John J Cooper; Hannah Florance; Matthew T Robinson; Stephen Michell
Journal: Surg Infect (Larchmt) Date: 2014-08-22 Impact factor: 2.150

3. Evaluation of two sources of calcium sulfate for a local drug delivery system: a pilot study.

Authors: Ashley C Parker; J Keaton Smith; Harry S Courtney; Warren O Haggard
Journal: Clin Orthop Relat Res Date: 2011-11 Impact factor: 4.176

Review 4. Management of acute hematogenous osteomyelitis in children.

Authors: Nada S Harik; Mark S Smeltzer
Journal: Expert Rev Anti Infect Ther Date: 2010-02 Impact factor: 5.091

5. Calcium sulphate mixed with antibiotics does not decrease efficacy against Cutibacterium acnes (formerly Propionibacterium acnes), in vitro study.

Authors: Anne Couture; Valéry Lavergne; Emilie Sandman; Jean-Michel Leduc; Benoit Benoit; Stéphane Leduc; Dominique M Rouleau
Journal: J Orthop Date: 2019-11-28

10. Development of a Novel Collagen Wound Model To Simulate the Activity and Distribution of Antimicrobials in Soft Tissue during Diabetic Foot Infection.

Authors: Bianca L Price; Andrew M Lovering; Frank L Bowling; Curtis B Dobson
Journal: Antimicrob Agents Chemother Date: 2016-10-21 Impact factor: 5.191