Literature DB >> 11418521

Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.

T A Wichelhaus1, E Dingeldein, M Rauschmann, S Kluge, R Dieterich, V Schäfer, V Brade.   

Abstract

The in vitro release of vancomycin, teicoplanin, gentamicin and clindamycin from biodegradable calcium sulphate (CaSO(4)) carrier beads is described. All antibiotics showed prolonged release from the carrier beads, which was elevated during the first 24 h, with peak levels exceeding 2500 microg/bead. Doubling the antibiotic load of the beads revealed a more prolonged elution and a two-fold increase in antibiotic release. Local carrier-associated antibiotic treatment with CaSO(4) beads may prove to be effective in the management of chronic bone infections.

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Year:  2001        PMID： 11418521     DOI： 10.1093/jac/48.1.117

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  19 in total

1.  [Collagen hydroxyapatite (Healos) saturated with gentamicin or levofloxacin. In vitro antimicrobial effectiveness - a pilot study].

Authors:  C H Fürstenberg; B Wiedenhöfer; C Putz; I Burckhardt; S Gantz; K Kleinschmidt; K Schröder
Journal:  Orthopade       Date:  2010-04       Impact factor: 1.087

2.  Composite chitosan and calcium sulfate scaffold for dual delivery of vancomycin and recombinant human bone morphogenetic protein-2.

Authors:  Heather A Doty; Megan R Leedy; Harry S Courtney; Warren O Haggard; Joel D Bumgardner
Journal:  J Mater Sci Mater Med       Date:  2014-02-07       Impact factor: 3.896

3.  Antibiotic-loaded synthetic calcium sulfate beads for prevention of bacterial colonization and biofilm formation in periprosthetic infections.

Authors:  R P Howlin; M J Brayford; J S Webb; J J Cooper; S S Aiken; P Stoodley
Journal:  Antimicrob Agents Chemother       Date:  2014-10-13       Impact factor: 5.191

4.  Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.

Authors:  Sean S Aiken; John J Cooper; Hannah Florance; Matthew T Robinson; Stephen Michell
Journal:  Surg Infect (Larchmt)       Date:  2014-08-22       Impact factor: 2.150

Review 5.  [Bone substitute materials as local drug carriers : Current status of substitutes of various origins].

Authors:  K-D Kühn; C Berberich; H Bösebeck
Journal:  Orthopade       Date:  2018-01       Impact factor: 1.087

6.  Successful Salvage of an Extracardiac Fontan in the Setting of Purulent Mediastinitis using Antibiotic-Impregnated Beads.

Authors:  Matthew T Coghill; Gonzalo A Wallis; Paul M Kirshbom; Thomas S Maxey
Journal:  J Pediatr Intensive Care       Date:  2018-02-06

7.  Antibiotic-loaded calcium carbonate/calcium sulfate granules as co-adjuvant for bone grafting.

Authors:  Débora C Coraça-Huber; Alexander Wurm; Manfred Fille; Johann Hausdorfer; Michael Nogler; S Vogt; Klaus-Dieter Kühn
Journal:  J Mater Sci Mater Med       Date:  2015-01-13       Impact factor: 3.896

8.  In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.

Authors:  Kyriaki Kanellakopoulou; Periklis Panagopoulos; Efthymia Giannitsioti; Thomas Tsaganos; Dionyssia-Pinelopi Carrer; Nicolas Efstathopoulos; Evangelos J Giamarellos-Bourboulis
Journal:  Antimicrob Agents Chemother       Date:  2009-04-27       Impact factor: 5.191

Review 9.  Review of calcium-sulphate-based ceramics and synthetic bone substitutes used for antibiotic delivery in PJI and osteomyelitis treatment.

Authors:  Razvan Ene; Mihai Nica; Dragos Ene; Adrian Cursaru; Catalin Cirstoiu
Journal:  EFORT Open Rev       Date:  2021-05-04

10.  Treatment of a chronic recurrent fistulized tibial osteomyelitis: administration of a novel antibiotic-loaded bone substitute combined with a pedicular muscle flap sealing.

Authors:  Massimo Franceschini; Adriano Di Matteo; Hans Bösebeck; Hubert Büchner; Sebastian Vogt
Journal:  Eur J Orthop Surg Traumatol       Date:  2012-02-19
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