Literature DB >> 10933660

Treatment of experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus with a biodegradable system of lactic acid polymer releasing pefloxacin.

K Kanellakopoulou1, N Galanakis, E J Giamarellos-Bourboulis, C Rifiotis, K Papakostas, A Andreopoulos, E Dounis, P Karagianakos, H Giamarellou.   

Abstract

A novel biodegradable system of D-,L-dilactide delivering pefloxacin was implanted in 104 rabbits with experimental osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA), 26 serving as controls. Animals were killed on each third day and viable bacterial counts and levels of pefloxacin in bone tissue were determined. A 99. 9% decrease in viable count of bacteria was achieved by day 12 and complete bacterial eradication on day 33. Pefloxacin was released gradually, reaching its peak on day 15 at levels 100 times the MIC of pefloxacin for MRSA. The biodegradable system described may have a future role in the therapeutic approach to osteomyelitis.

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Year:  2000        PMID： 10933660     DOI： 10.1093/jac/46.2.311

Source DB:  PubMed          Journal:  J Antimicrob Chemother        ISSN： 0305-7453            Impact factor:   5.790


  4 in total

1.  Efficacy of ciprofloxacin-releasing bioabsorbable osteoconductive bone defect filler for treatment of experimental osteomyelitis due to Staphylococcus aureus.

Authors:  Jyri K Koort; Tatu J Mäkinen; Esa Suokas; Minna Veiranto; Jari Jalava; Juhani Knuuti; Pertti Törmälä; Hannu T Aro
Journal:  Antimicrob Agents Chemother       Date:  2005-04       Impact factor: 5.191

2.  In vitro elution of daptomycin by a synthetic crystallic semihydrate form of calcium sulfate, stimulan.

Authors:  Kyriaki Kanellakopoulou; Periklis Panagopoulos; Efthymia Giannitsioti; Thomas Tsaganos; Dionyssia-Pinelopi Carrer; Nicolas Efstathopoulos; Evangelos J Giamarellos-Bourboulis
Journal:  Antimicrob Agents Chemother       Date:  2009-04-27       Impact factor: 5.191

3.  Local treatment of experimental Pseudomonas aeruginosa osteomyelitis with a biodegradable dilactide polymer releasing ciprofloxacin.

Authors:  Kyriaki Kanellakopoulou; George C Thivaios; Maria Kolia; Ismini Dontas; Lydia Nakopoulou; Eleftherios Dounis; Evangelos J Giamarellos-Bourboulis; Andreas Andreopoulos; Panayotis Karagiannakos; Helen Giamarellou
Journal:  Antimicrob Agents Chemother       Date:  2008-04-14       Impact factor: 5.191

4.  In vitro elution characteristics of gentamicin and vancomycin from synthetic bone graft substitutes.

Authors:  Gerrit Steffen Maier; Klaus Edgar Roth; Stefan Andereya; Klaus Birnbaum; Christopher Niedhart; Markus Lühmann; Jörg Ohnsorge; Uwe Maus
Journal:  Open Orthop J       Date:  2013-11-03
  4 in total

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