Literature DB >> 19369534

Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.

John Tapsall1, Phillip Read2, Christopher Carmody3, Christopher Bourne2, Sanghamitra Ray1, Athena Limnios1, Theo Sloots4, David Whiley4.   

Abstract

Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l(-1), which may have contributed to the treatment failures in these cases.

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Year:  2009        PMID： 19369534     DOI： 10.1099/jmm.0.007641-0

Source DB:  PubMed          Journal:  J Med Microbiol        ISSN： 0022-2615            Impact factor:   2.472


  46 in total

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