Literature DB >> 23183436

Neisseria gonorrhoeae strain with high-level resistance to spectinomycin due to a novel resistance mechanism (mutated ribosomal protein S5) verified in Norway.

Magnus Unemo1, Daniel Golparian, Vegard Skogen, Anne Olaug Olsen, Harald Moi, Gaute Syversen, Stig Ove Hjelmevoll.   

Abstract

Gonorrhea may become untreatable, and new treatment options are essential. Verified resistance to spectinomycin is exceedingly rare. However, we describe a high-level spectinomycin-resistant (MIC, >1,024 μg/ml) Neisseria gonorrhoeae strain from Norway with a novel resistance mechanism. The resistance determinant was a deletion of codon 27 (valine) and a K28E alteration in the ribosomal protein 5S. The traditional spectinomycin resistance gene (16S rRNA) was wild type. Despite this exceedingly rare finding, spectinomycin available for treatment of ceftriaxone-resistant urogenital gonorrhea would be very valuable.

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Year:  2012        PMID： 23183436      PMCID： PMC3553714          DOI： 10.1128/AAC.01775-12

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  51 in total

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Journal:  Mol Gen Genet       Date:  1985

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Authors:  P C Makosky; A E Dahlberg
Journal:  Biochimie       Date:  1987-08       Impact factor: 4.079

3.  Spectinomycin resistance in Neisseria spp. due to mutations in 16S rRNA.

Authors:  M Galimand; G Gerbaud; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

4.  Treatment of uncomplicated gonococcal urethritis by double-dosing of 200 mg cefixime at a 6-h interval.

Authors:  Takashi Deguchi; Mitsuru Yasuda; Shigeaki Yokoi; Ken-Ichiro Ishida; Masayasu Ito; Satoshi Ishihara; Ken Minamidate; Yoshimasa Harada; Kanhin Tei; Kentaro Kojima; Masayoshi Tamaki; Shin-Ichi Maeda
Journal:  J Infect Chemother       Date:  2003-03       Impact factor: 2.211

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Authors:  D Moazed; H F Noller
Journal:  Nature       Date:  1987 Jun 4-10       Impact factor: 49.962

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Journal:  Mol Gen Genet       Date:  1972

7.  Antibiotic resistance mutations in 16S and 23S ribosomal RNA genes of Escherichia coli.

Authors:  C D Sigmund; M Ettayebi; E A Morgan
Journal:  Nucleic Acids Res       Date:  1984-06-11       Impact factor: 16.971

Review 8.  Effectiveness of gentamicin for gonorrhoea treatment: systematic review and meta-analysis.

Authors:  Deborah Dowell; Robert D Kirkcaldy
Journal:  Sex Transm Infect       Date:  2012-08-23       Impact factor: 3.519

9.  Effect of spectinomycin use on the prevalence of spectinomycin-resistant and of penicillinase-producing Neisseria gonorrhoeae.

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Journal:  N Engl J Med       Date:  1987-07-30       Impact factor: 91.245

10.  Ribosomal RNA and protein mutants resistant to spectinomycin.

Authors:  N Bilgin; A A Richter; M Ehrenberg; A E Dahlberg; C G Kurland
Journal:  EMBO J       Date:  1990-03       Impact factor: 11.598
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  34 in total

Review 1.  Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.

Authors:  Magnus Unemo; William M Shafer
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

2.  The Loop 2 Region of Ribosomal Protein uS5 Influences Spectinomycin Sensitivity, Translational Fidelity, and Ribosome Biogenesis.

Authors:  Divya Kamath; Steven T Gregory; Michael O'Connor
Journal:  Antimicrob Agents Chemother       Date:  2017-01-24       Impact factor: 5.191

Review 3.  Neisseria gonorrhoeae Antimicrobial Resistance: Past to Present to Future.

Authors:  Georgina L Aitolo; Oluyomi S Adeyemi; Boluwatife L Afolabi; Akinyomade O Owolabi
Journal:  Curr Microbiol       Date:  2021-02-02       Impact factor: 2.188

4.  Mechanisms of Resistance to Aminoglycoside Antibiotics: Overview and Perspectives.

Authors:  Sylvie Garneau-Tsodikova; Kristin J Labby
Journal:  Medchemcomm       Date:  2015-09-21       Impact factor: 3.597

5.  Evaluation of the Microbiological Efficacy of a Single 2-Gram Dose of Extended-Release Azithromycin by Population Pharmacokinetics and Simulation in Japanese Patients with Gonococcal Urethritis.

Authors:  Midori Soda; Shin Ito; Naoki Matsumaru; Sakiko Nakamura; Izumi Nagase; Hikari Takahashi; Yuta Ohno; Mitsuru Yasuda; Miho Yamamoto; Katsura Tsukamoto; Yoshinori Itoh; Takashi Deguchi; Kiyoyuki Kitaichi
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

Review 6.  Applications of genomics to slow the spread of multidrug-resistant Neisseria gonorrhoeae.

Authors:  Tatum D Mortimer; Yonatan H Grad
Journal:  Ann N Y Acad Sci       Date:  2018-06-06       Impact factor: 5.691

Review 7.  Destination of aminoglycoside antibiotics in the 'post-antibiotic era'.

Authors:  Yoshiaki Takahashi; Masayuki Igarashi
Journal:  J Antibiot (Tokyo)       Date:  2017-10-25       Impact factor: 2.649

8.  Whole-Genome Sequence Analysis of Multidrug-Resistant Campylobacter Isolates: a Focus on Aminoglycoside Resistance Determinants.

Authors:  Adrien Fabre; Monica Oleastro; Alexandra Nunes; Andrea Santos; Elodie Sifré; Astrid Ducournau; Lucie Bénéjat; Alice Buissonnière; Pauline Floch; Francis Mégraud; Véronique Dubois; Philippe Lehours
Journal:  J Clin Microbiol       Date:  2018-08-27       Impact factor: 5.948

Review 9.  The evolving role of chemical synthesis in antibacterial drug discovery.

Authors:  Peter M Wright; Ian B Seiple; Andrew G Myers
Journal:  Angew Chem Int Ed Engl       Date:  2014-07-02       Impact factor: 15.336

Review 10.  Antimicrobial Resistance Expressed by Neisseria gonorrhoeae: A Major Global Public Health Problem in the 21st Century.

Authors:  Magnus Unemo; Carlos Del Rio; William M Shafer
Journal:  Microbiol Spectr       Date:  2016-06
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