Literature DB >> 25199775

In Vitro selection of Neisseria gonorrhoeae mutants with elevated MIC values and increased resistance to cephalosporins.

Steven R Johnson1, Yonatan Grad2, Satishkumar Ranganathan Ganakammal3, Mark Burroughs4, Mike Frace3, Marc Lipsitch5, Ryan Weil3, David Trees6.   

Abstract

Strains of Neisseria gonorrhoeae with mosaic penA genes bearing novel point mutations in penA have been isolated from ceftriaxone treatment failures. Such isolates exhibit significantly higher MIC values to third-generation cephalosporins. Here we report the in vitro isolation of two mutants with elevated MICs to cephalosporins. The first possesses a point mutation in the transpeptidase region of the mosaic penA gene, and the second contains an insertion mutation in pilQ.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 25199775      PMCID： PMC4249396          DOI： 10.1128/AAC.03082-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

1.  A mutant form of the Neisseria gonorrhoeae pilus secretin protein PilQ allows increased entry of heme and antimicrobial compounds.

Authors:  Ching-ju Chen; Deborah M Tobiason; Christopher E Thomas; William M Shafer; H Steven Seifert; P Frederick Sparling
Journal:  J Bacteriol       Date:  2004-02       Impact factor: 3.490

2.  Overexpression of the MtrC-MtrD-MtrE efflux pump due to an mtrR mutation is required for chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

Authors:  Wendy L Veal; Robert A Nicholas; William M Shafer
Journal:  J Bacteriol       Date:  2002-10       Impact factor: 3.490

3.  Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species.

Authors:  B G Spratt; L D Bowler; Q Y Zhang; J Zhou; J M Smith
Journal:  J Mol Evol       Date:  1992-02       Impact factor: 2.395

4.  Insertion of an extra amino acid is the main cause of the low affinity of penicillin-binding protein 2 in penicillin-resistant strains of Neisseria gonorrhoeae.

Authors:  J A Brannigan; I A Tirodimos; Q Y Zhang; C G Dowson; B G Spratt
Journal:  Mol Microbiol       Date:  1990-06       Impact factor: 3.501

5.  Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

Authors:  Patricia A Ropp; Mei Hu; Melanie Olesky; Robert A Nicholas
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

6.  Identification of amino acids conferring high-level resistance to expanded-spectrum cephalosporins in the penA gene from Neisseria gonorrhoeae strain H041.

Authors:  Joshua Tomberg; Magnus Unemo; Makoto Ohnishi; Christopher Davies; Robert A Nicholas
Journal:  Antimicrob Agents Chemother       Date:  2013-04-15       Impact factor: 5.191

7.  Mutations causing in vitro resistance to azithromycin in Neisseria gonorrhoeae.

Authors:  Steven R Johnson; Amy L Sandul; Manhar Parekh; Susan A Wang; Joan S Knapp; David L Trees
Journal:  Int J Antimicrob Agents       Date:  2003-05       Impact factor: 5.283

8.  Resistance of Neisseria gonorrhoeae to antimicrobial hydrophobic agents is modulated by the mtrRCDE efflux system.

Authors:  K E Hagman; W Pan; B G Spratt; J T Balthazar; R C Judd; W M Shafer
Journal:  Microbiology       Date:  1995-03       Impact factor: 2.777

9.  Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro.

Authors:  D S Kellogg; I R Cohen; L C Norins; A L Schroeter; G Reising
Journal:  J Bacteriol       Date:  1968-09       Impact factor: 3.490

10.  Mosaic-like structure of penicillin-binding protein 2 Gene (penA) in clinical isolates of Neisseria gonorrhoeae with reduced susceptibility to cefixime.

Authors:  Satoshi Ameyama; Shoichi Onodera; Masahiro Takahata; Shinzaburo Minami; Nobuko Maki; Katsuhisa Endo; Hirokazu Goto; Hiroo Suzuki; Yukihiko Oishi
Journal:  Antimicrob Agents Chemother       Date:  2002-12       Impact factor: 5.191
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  11 in total

1.  In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae.

Authors:  Evelyn E Nash; Tara C Henning; Cau D Pham; Kevin Pettus; Samera Sharpe; Ellen N Kersh
Journal:  Diagn Microbiol Infect Dis       Date:  2018-11-10       Impact factor: 2.803

2.  A Single Amino Acid Substitution in Elongation Factor G Can Confer Low-Level Gentamicin Resistance in Neisseria gonorrhoeae.

Authors:  Concerta L Holley; Vijaya Dhulipala; Jacqueline T Balthazar; Adriana Le Van; Afrin A Begum; Shao-Chun Chen; Timothy D Read; Mitch Matoga; Irving F Hoffman; Daniel Golparian; Magnus Unemo; Ann E Jerse; William M Shafer
Journal:  Antimicrob Agents Chemother       Date:  2022-04-25       Impact factor: 5.938

3.  Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013.

Authors:  Yonatan H Grad; Simon R Harris; Robert D Kirkcaldy; Anna G Green; Debora S Marks; Stephen D Bentley; David Trees; Marc Lipsitch
Journal:  J Infect Dis       Date:  2016-09-16       Impact factor: 5.226

4.  Comparing the disk-diffusion and agar dilution tests for Neisseria gonorrhoeae antimicrobial susceptibility testing.

Authors:  Hsi Liu; Thomas H Taylor; Kevin Pettus; Steve Johnson; John R Papp; David Trees
Journal:  Antimicrob Resist Infect Control       Date:  2016-11-24       Impact factor: 4.887

Review 5.  Environmental and genetic modulation of the phenotypic expression of antibiotic resistance.

Authors:  Diarmaid Hughes; Dan I Andersson
Journal:  FEMS Microbiol Rev       Date:  2017-05-01       Impact factor: 16.408

6.  RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates.

Authors:  Samantha G Palace; Yi Wang; Daniel Hf Rubin; Michael A Welsh; Tatum D Mortimer; Kevin Cole; David W Eyre; Suzanne Walker; Yonatan H Grad
Journal:  Elife       Date:  2020-02-03       Impact factor: 8.140

7.  The serogroup B meningococcal outer membrane vesicle-based vaccine 4CMenB induces cross-species protection against Neisseria gonorrhoeae.

Authors:  Isabelle Leduc; Kristie L Connolly; Afrin Begum; Knashka Underwood; Stephen Darnell; William M Shafer; Jacqueline T Balthazar; Andrew N Macintyre; Gregory D Sempowski; Joseph A Duncan; Marguerite B Little; Nazia Rahman; Eric C Garges; Ann E Jerse
Journal:  PLoS Pathog       Date:  2020-12-08       Impact factor: 6.823

8.  Heteroresistance to the model antimicrobial peptide polymyxin B in the emerging Neisseria meningitidis lineage 11.2 urethritis clade: mutations in the pilMNOPQ operon.

Authors:  Yih-Ling Tzeng; Zachary Berman; Evelyn Toh; Jose A Bazan; Abigail Norris Turner; Adam C Retchless; Xin Wang; David E Nelson; David S Stephens
Journal:  Mol Microbiol       Date:  2018-11-13       Impact factor: 3.979

Review 9.  Resistance to β-Lactams in Neisseria ssp Due to Chromosomally Encoded Penicillin-Binding Proteins.

Authors:  André Zapun; Cécile Morlot; Muhamed-Kheir Taha
Journal:  Antibiotics (Basel)       Date:  2016-09-28

10.  Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae.

Authors:  Crista B Wadsworth; Brian J Arnold; Mohamad R Abdul Sater; Yonatan H Grad
Journal:  mBio       Date:  2018-08-07       Impact factor: 7.867
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