Literature DB >> 26482313

Multidrug-Resistant Neisseria gonorrhoeae Isolates from Nanjing, China, Are Sensitive to Killing by a Novel DNA Gyrase Inhibitor, ETX0914 (AZD0914).

Xiao-Hong Su1, Bao-Xi Wang2, Wen-Jing Le1, Yu-Rong Liu1, Chuan Wan1, Sai Li1, Richard A Alm3, John P Mueller4, Peter A Rice5.   

Abstract

We tested the activity of ETX0914 against 187 Neisseria gonorrhoeae isolates from men with urethritis in Nanjing, China, in 2013. The MIC50, MIC90, and MIC range for ETX0914 were 0.03 μg/ml, 0.06 μg/ml, and ≤0.002 to 0.125 μg/ml, respectively. All isolates were resistant to ciprofloxacin, and 36.9% (69/187) were resistant to azithromycin. Of the isolates, 46.5% were penicillinase-producing N. gonorrhoeae (PPNG), 36% were tetracycline-resistant N. gonorrhoeae (TRNG), and 13% (24 isolates) had an MIC of 0.125 μg/ml for ceftriaxone. ETX0914 may be an effective treatment option for gonorrhea.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26482313      PMCID： PMC4704236          DOI： 10.1128/AAC.01211-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  24 in total

1.  Treatment failure of pharyngeal gonorrhoea with internationally recommended first-line ceftriaxone verified in Slovenia, September 2011.

Authors:  M Unemo; D Golparian; M Potočnik; S Jeverica
Journal:  Euro Surveill       Date:  2012-06-21

2.  Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010.

Authors:  M Unemo; D Golparian; G Syversen; D F Vestrheim; H Moi
Journal:  Euro Surveill       Date:  2010-11-25

3.  Sexually transmitted diseases treatment guidelines, 2015.

Authors:  Kimberly A Workowski; Gail A Bolan
Journal:  MMWR Recomm Rep       Date:  2015-06-05

4.  Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

Authors:  Gunther Kern; Tiffany Palmer; David E Ehmann; Adam B Shapiro; Beth Andrews; Gregory S Basarab; Peter Doig; Jun Fan; Ning Gao; Scott D Mills; John Mueller; Shubha Sriram; Jason Thresher; Grant K Walkup
Journal:  J Biol Chem       Date:  2015-07-06       Impact factor: 5.157

5.  Simple method for detecting penicillinase-producing Neisseria gonorrhoeae and Staphylococcus aureus.

Authors:  E H Sng; K L Yeo; V S Rajan
Journal:  Br J Vener Dis       Date:  1981-04

6.  High in vitro susceptibility to the novel spiropyrimidinetrione ETX0914 (AZD0914) among 873 contemporary clinical Neisseria gonorrhoeae isolates from 21 European countries from 2012 to 2014.

Authors:  Magnus Unemo; Johan Ringlander; Catherine Wiggins; Hans Fredlund; Susanne Jacobsson; Michelle Cole
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

7.  In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens.

Authors:  Douglas J Biedenbach; Michael D Huband; Meredith Hackel; Boudewijn L M de Jonge; Daniel F Sahm; Patricia A Bradford
Journal:  Antimicrob Agents Chemother       Date:  2015-07-20       Impact factor: 5.191

8.  Surveillance of antimicrobial susceptibilities in Neisseria gonorrhoeae in Nanjing, China, 1999-2006.

Authors:  Xiaohong Su; Faxing Jiang; Xiuqing Dai; Houhua Sun; Shunzhang Ye
Journal:  Sex Transm Dis       Date:  2007-12       Impact factor: 2.830

9.  Two cases of failed ceftriaxone treatment in pharyngeal gonorrhoea verified by molecular microbiological methods.

Authors:  John Tapsall; Phillip Read; Christopher Carmody; Christopher Bourne; Sanghamitra Ray; Athena Limnios; Theo Sloots; David Whiley
Journal:  J Med Microbiol       Date:  2009-05       Impact factor: 2.472

10.  Ceftriaxone-resistant Neisseria gonorrhoeae, Japan.

Authors:  Makoto Ohnishi; Takeshi Saika; Shinji Hoshina; Kazuhiro Iwasaku; Shu-ichi Nakayama; Haruo Watanabe; Jo Kitawaki
Journal:  Emerg Infect Dis       Date:  2011-01       Impact factor: 6.883
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  7 in total

1.  High in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among consecutive clinical Neisseria gonorrhoeae isolates from Thailand (2018) and South Africa (2015-2017).

Authors:  Susanne Jacobsson; Ranmini Kularatne; Rossaphorn Kittiyaowamarn; Venessa Maseko; Porntip Paopang; Pongsathorn Sangprasert; Pachara Sirivongrangson; Laura Piddock; Teodora Wi; Emilie Alirol; Magnus Unemo
Journal:  Antimicrob Agents Chemother       Date:  2019-09-23       Impact factor: 5.191

2.  Determination of MIC Quality Control Ranges for the Novel Gyrase Inhibitor Zoliflodacin.

Authors:  Alita A Miller; Maria M Traczewski; Michael D Huband; Patricia A Bradford; John P Mueller
Journal:  J Clin Microbiol       Date:  2019-08-26       Impact factor: 5.948

Review 3.  Molecular Regulatory Mechanisms Drive Emergent Pathogenetic Properties of Neisseria gonorrhoeae.

Authors:  Ashwini Sunkavalli; Ryan McClure; Caroline Genco
Journal:  Microorganisms       Date:  2022-04-28

4.  Increasing Resistance to Azithromycin in Neisseria gonorrhoeae in Eastern Chinese Cities: Resistance Mechanisms and Genetic Diversity among Isolates from Nanjing.

Authors:  Chuan Wan; Yang Li; Wen-Jing Le; Yu-Rong Liu; Sai Li; Bao-Xi Wang; Peter A Rice; Xiao-Hong Su
Journal:  Antimicrob Agents Chemother       Date:  2018-04-26       Impact factor: 5.191

5.  Systematic review and survey of Neisseria gonorrhoeae ceftriaxone and azithromycin susceptibility data in the Asia Pacific, 2011 to 2016.

Authors:  C R Robert George; Rodney P Enriquez; Barrie J Gatus; David M Whiley; Ying-Ru Lo; Naoko Ishikawa; Teodora Wi; Monica M Lahra
Journal:  PLoS One       Date:  2019-04-03       Impact factor: 3.240

Review 6.  Azithromycin resistant gonococci: a literature review.

Authors:  Awoke Derbie; Daniel Mekonnen; Yimtubezinash Woldeamanuel; Tamrat Abebe
Journal:  Antimicrob Resist Infect Control       Date:  2020-08-18       Impact factor: 4.887

7.  Global Network Analysis of Neisseria gonorrhoeae Identifies Coordination between Pathways, Processes, and Regulators Expressed during Human Infection.

Authors:  Ryan McClure; Ashwini Sunkavalli; Phillip M Balzano; Paola Massari; Christine Cho; William M Nauseef; Michael A Apicella; Caroline A Genco
Journal:  mSystems       Date:  2020-02-04       Impact factor: 6.496
  7 in total

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