BACKGROUND: Optimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients. METHODS: Ninety-three (30%) of 311 patients with ILC received NAC. We examined margin status, residual disease after re-excision, and clinical outcomes. RESULTS: Margin positivity rates after the final operative procedure were similar between the NAC and surgery-first group (P > .05). The proportion of patients, stratified by margin status, who were taken back for re-excision was not different between the 2 groups, and, similarly, there were no differences in frequency of residual disease (all P > .05). At a median follow-up of 3.1 years, 1 patient in the NAC group and 2 in the surgery-first group developed LR (P = 1.0). CONCLUSIONS: Patients with ILC who have undergone NAC and have margins >1 mm have a low probability of residual disease and LR.
BACKGROUND: Optimal surgical management of patients with invasive lobular carcinoma (ILC) who undergo neoadjuvant chemotherapy (NAC) is unknown. We evaluated optimal margin distance and local recurrence (LR) rates for these patients. METHODS: Ninety-three (30%) of 311 patients with ILC received NAC. We examined margin status, residual disease after re-excision, and clinical outcomes. RESULTS: Margin positivity rates after the final operative procedure were similar between the NAC and surgery-first group (P > .05). The proportion of patients, stratified by margin status, who were taken back for re-excision was not different between the 2 groups, and, similarly, there were no differences in frequency of residual disease (all P > .05). At a median follow-up of 3.1 years, 1 patient in the NAC group and 2 in the surgery-first group developed LR (P = 1.0). CONCLUSIONS:Patients with ILC who have undergone NAC and have margins >1 mm have a low probability of residual disease and LR.
Authors: N van den Broek; M J C van der Sangen; L V van de Poll-Franse; M W P M van Beek; G A P Nieuwenhuijzen; A C Voogd Journal: Breast Cancer Res Treat Date: 2006-11-18 Impact factor: 4.872
Authors: Thao N Vo; Funda Meric-Bernstam; Min Yi; Thomas A Buchholz; Frederick C Ames; Henry M Kuerer; Isabelle Bedrosian; Kelly K Hunt Journal: Am J Surg Date: 2006-10 Impact factor: 2.565
Authors: M Bouvet; D W Ollila; K K Hunt; G V Babiera; F R Spitz; A E Giuliano; E A Strom; F C Ames; M I Ross; S E Singletary Journal: Ann Surg Oncol Date: 1997-12 Impact factor: 5.344
Authors: M Tubiana-Hulin; D Stevens; S Lasry; J M Guinebretière; L Bouita; C Cohen-Solal; P Cherel; J Rouëssé Journal: Ann Oncol Date: 2006-06-01 Impact factor: 32.976
Authors: G Peiro; B A Bornstein; J L Connolly; R Gelman; S Hetelekidis; A J Nixon; A Recht; B Silver; J R Harris; S J Schnitt Journal: Breast Cancer Res Treat Date: 2000-01 Impact factor: 4.872
Authors: Massimo Cristofanilli; Ana Gonzalez-Angulo; Nour Sneige; Shu-Wan Kau; Kristine Broglio; Richard L Theriault; Vicente Valero; Aman U Buzdar; Henry Kuerer; Thomas A Buchholz; Thomas A Buccholz; Gabriel N Hortobagyi Journal: J Clin Oncol Date: 2005-01-01 Impact factor: 44.544
Authors: Judy C Boughey; Jamie Wagner; Betsy J Garrett; Lori Harker; Lavinia P Middleton; Gildy V Babiera; Funda Meric-Bernstam; Anthony Lucci; Kelly K Hunt; Isabelle Bedrosian Journal: Ann Surg Oncol Date: 2009-03-12 Impact factor: 5.344
Authors: Marieke E M van der Noordaa; Ileana Ioan; Emiel J Rutgers; Erik van Werkhoven; Claudette E Loo; Rosie Voorthuis; Jelle Wesseling; Japke van Urk; Terry Wiersma; Vincent Dezentje; Marie-Jeanne T F D Vrancken Peeters; Frederieke H van Duijnhoven Journal: Ann Surg Oncol Date: 2021-05-12 Impact factor: 5.344
Authors: Y Delpech; C Coutant; L Hsu; E Barranger; T Iwamoto; C H Barcenas; G N Hortobagyi; R Rouzier; F J Esteva; L Pusztai Journal: Br J Cancer Date: 2013-01-08 Impact factor: 7.640
Authors: Merisa L Piper; Jasmine Wong; Kelly Fahrner-Scott; Cheryl Ewing; Michael Alvarado; Laura J Esserman; Rita A Mukhtar Journal: NPJ Breast Cancer Date: 2019-09-06