Literature DB >> 19356087

Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS.

Besnik Bajrami1, Sadagopan Krishnan, James F Rusling.   

Abstract

Rat liver microsomes attached to nanoparticles were used for LC-MS studies of CYP3A and 2E1 enzymes in metabolism of N-nitroso compounds. Using these biocolloids, turnover rates were measured within 2 min. Inhibitor IC(50) values for ketoconazole (KET) and 4-methylpyrazole (4-MEP) were estimated.

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Year:  2008        PMID： 19356087      PMCID： PMC3473178          DOI： 10.2174/187231208785425854

Source DB:  PubMed          Journal:  Drug Metab Lett        ISSN： 1872-3128


  24 in total

1.  Evidence for cytochrome P450 2A6 and 3A4 as major catalysts for N'-nitrosonornicotine alpha-hydroxylation by human liver microsomes.

Authors:  C J Patten; T J Smith; M J Friesen; R E Tynes; C S Yang; S E Murphy
Journal:  Carcinogenesis       Date:  1997-08       Impact factor: 4.944

2.  Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens.

Authors:  Mingyao Wang; Guang Cheng; Shana J Sturla; Yongli Shi; Edward J McIntee; Peter W Villalta; Pramod Upadhyaya; Stephen S Hecht
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Review 3.  A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans.

Authors:  D D Breimer; J H Schellens
Journal:  Trends Pharmacol Sci       Date:  1990-06       Impact factor: 14.819

4.  Electrochemiluminescent arrays for cytochrome P450-activated genotoxicity screening. DNA damage from benzo[a]pyrene metabolites.

Authors:  Eli G Hvastkovs; Minjeong So; Sadagopan Krishnan; Besnik Bajrami; Maricar Tarun; Ingela Jansson; John B Schenkman; James F Rusling
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5.  High-throughput cytochrome P450 (CYP) inhibition screening via cassette probe-dosing strategy. I. Development of direct injection/on-line guard cartridge extraction/tandem mass spectrometry for the simultaneous detection of CYP probe substrates and their metabolites.

Authors:  H Z Bu; L Magis; K Knuth; P Teitelbaum
Journal:  Rapid Commun Mass Spectrom       Date:  2000       Impact factor: 2.419

6.  High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isozymes CYP2A6, 3A4, 2C9, 2D6 and 2E1.

Authors:  H Z Bu; L Magis; K Knuth; P Teitelbaum
Journal:  Rapid Commun Mass Spectrom       Date:  2001       Impact factor: 2.419

7.  Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.

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Journal:  Drug Metab Dispos       Date:  2003-10       Impact factor: 3.922

8.  Preferential metabolic activation of N-nitrosopiperidine as compared to its structural homologue N-nitrosopyrrolidine by rat nasal mucosal microsomes.

Authors:  Hansen L Wong; Sharon E Murphy; Stephen S Hecht
Journal:  Chem Res Toxicol       Date:  2003-10       Impact factor: 3.739

Review 9.  Tobacco carcinogens, their biomarkers and tobacco-induced cancer.

Authors:  Stephen S Hecht
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Authors:  Besnik Bajrami; Eli G Hvastkovs; Gary C Jensen; John B Schenkman; James F Rusling
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  14 in total

1.  High-throughput metabolic toxicity screening using magnetic biocolloid reactors and LC-MS/MS.

Authors:  Linlin Zhao; John B Schenkman; James F Rusling
Journal:  Anal Chem       Date:  2010-11-19       Impact factor: 6.986

2.  High-throughput metabolic genotoxicity screening with a fluidic microwell chip and electrochemiluminescence.

Authors:  Dhanuka P Wasalathanthri; Spundana Malla; Itti Bist; Chi K Tang; Ronaldo C Faria; James F Rusling
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Review 5.  Metabolic toxicity screening using electrochemiluminescence arrays coupled with enzyme-DNA biocolloid reactors and liquid chromatography-mass spectrometry.

Authors:  Eli G Hvastkovs; John B Schenkman; James F Rusling
Journal:  Annu Rev Anal Chem (Palo Alto Calif)       Date:  2012-04-05       Impact factor: 10.745

6.  Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format.

Authors:  Besnik Bajrami; Linlin Zhao; John B Schenkman; James F Rusling
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7.  Characterizing metabolic inhibition using electrochemical enzyme/DNA biosensors.

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8.  Organ-Specific Screening for Protein Damage Using Magnetic Bead Bioreactors and LC-MS/MS.

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9.  Comparison of DNA-Reactive Metabolites from Nitrosamine and Styrene Using Voltammetric DNA/Microsomes Sensors.

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Review 10.  Thin multicomponent films for functional enzyme devices and bioreactor particles.

Authors:  James F Rusling; Dhanuka P Wasalathanthri; John B Schenkman
Journal:  Soft Matter       Date:  2014-11-07       Impact factor: 3.679
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