Literature DB >> 19337289

Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies.

Isaac T W Harley1, Kenneth M Kaufman, Carl D Langefeld, John B Harley, Jennifer A Kelly.   

Abstract

Genome-wide association studies and fine mapping of candidate regions have rapidly advanced our understanding of the genetic basis of systemic lupus erythematosus (SLE). More than 20 robust associations have now been identified and confirmed, providing insights at the molecular level that refine our understanding of the involvement of host immune response processes. In addition, genes with unknown roles in SLE pathophysiology have been identified. These findings may provide new routes towards improved clinical management of this complex disease.

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Year:  2009        PMID： 19337289      PMCID： PMC2737697          DOI： 10.1038/nrg2571

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  48 in total

1.  Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.

Authors:  Deborah S Cunninghame Graham; Harinder Manku; Susanne Wagner; Julia Reid; Kirsten Timms; Alexander Gutin; Jerry S Lanchbury; Tim J Vyse
Journal:  Hum Mol Genet       Date:  2006-12-22       Impact factor: 6.150

2.  A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus.

Authors:  Swapan K Nath; Shizhong Han; Xana Kim-Howard; Jennifer A Kelly; Parvathi Viswanathan; Gary S Gilkeson; Wei Chen; Cheng Zhu; Rodger P McEver; Robert P Kimberly; Marta E Alarcón-Riquelme; Timothy J Vyse; Quan-Zhen Li; Edward K Wakeland; Joan T Merrill; Judith A James; Kenneth M Kaufman; Joel M Guthridge; John B Harley
Journal:  Nat Genet       Date:  2008-01-20       Impact factor: 38.330

3.  Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus.

Authors:  Jeffrey C Edberg; Carl D Langefeld; Jianming Wu; Kathy L Moser; Kenneth M Kaufman; Jennifer Kelly; Vipin Bansal; W Mark Brown; Jane E Salmon; Stephen S Rich; John B Harley; Robert P Kimberly
Journal:  Arthritis Rheum       Date:  2002-08

4.  A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.

Authors:  Valeria Orrú; Sophia J Tsai; Blanca Rueda; Edoardo Fiorillo; Stephanie M Stanford; Jhimli Dasgupta; Jaana Hartiala; Lei Zhao; Norberto Ortego-Centeno; Sandra D'Alfonso; Frank C Arnett; Hui Wu; Miguel A Gonzalez-Gay; Betty P Tsao; Bernardo Pons-Estel; Marta E Alarcon-Riquelme; Yantao He; Zhong-Yin Zhang; Hooman Allayee; Xiaojiang S Chen; Javier Martin; Nunzio Bottini
Journal:  Hum Mol Genet       Date:  2008-11-03       Impact factor: 6.150

5.  An unusual haplotype structure on human chromosome 8p23 derived from the inversion polymorphism.

Authors:  Libin Deng; Yuezheng Zhang; Jian Kang; Tao Liu; Hongbin Zhao; Yang Gao; Chaohua Li; Hao Pan; Xiaoli Tang; Dunmei Wang; Tianhua Niu; Huanming Yang; Changqing Zeng
Journal:  Hum Mutat       Date:  2008-10       Impact factor: 4.878

6.  Trex1 prevents cell-intrinsic initiation of autoimmunity.

Authors:  Daniel B Stetson; Joan S Ko; Thierry Heidmann; Ruslan Medzhitov
Journal:  Cell       Date:  2008-08-22       Impact factor: 41.582

7.  Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans.

Authors:  Yan Yang; Erwin K Chung; Yee Ling Wu; Stephanie L Savelli; Haikady N Nagaraja; Bi Zhou; Maddie Hebert; Karla N Jones; Yaoling Shu; Kathryn Kitzmiller; Carol A Blanchong; Kim L McBride; Gloria C Higgins; Robert M Rennebohm; Robert R Rice; Kevin V Hackshaw; Robert A S Roubey; Jennifer M Grossman; Betty P Tsao; Daniel J Birmingham; Brad H Rovin; Lee A Hebert; C Yung Yu
Journal:  Am J Hum Genet       Date:  2007-04-26       Impact factor: 11.025

8.  Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

Authors:  Stacy L Musone; Kimberly E Taylor; Timothy T Lu; Joanne Nititham; Ricardo C Ferreira; Ward Ortmann; Nataliya Shifrin; Michelle A Petri; M Ilyas Kamboh; Susan Manzi; Michael F Seldin; Peter K Gregersen; Timothy W Behrens; Averil Ma; Pui-Yan Kwok; Lindsey A Criswell
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

9.  Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Authors:  Robert R Graham; Chris Cotsapas; Leela Davies; Rachel Hackett; Christopher J Lessard; Joanlise M Leon; Noel P Burtt; Candace Guiducci; Melissa Parkin; Casey Gates; Robert M Plenge; Timothy W Behrens; Joan E Wither; John D Rioux; Paul R Fortin; Deborah Cunninghame Graham; Andrew K Wong; Timothy J Vyse; Mark J Daly; David Altshuler; Kathy L Moser; Patrick M Gaffney
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

Review 10.  Developments in the scientific understanding of lupus.

Authors:  Stacy P Ardoin; David S Pisetsky
Journal:  Arthritis Res Ther       Date:  2008-10-10       Impact factor: 5.156
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  122 in total

1.  Myeloid dendritic cells from B6.NZM Sle1/Sle2/Sle3 lupus-prone mice express an IFN signature that precedes disease onset.

Authors:  Uma Sriram; Linda Varghese; Heather L Bennett; Neelakshi R Jog; Debra K Shivers; Yue Ning; Edward M Behrens; Roberto Caricchio; Stefania Gallucci
Journal:  J Immunol       Date:  2012-06-01       Impact factor: 5.422

Review 2.  Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

Authors:  Samuel E Vaughn; Leah C Kottyan; Melissa E Munroe; John B Harley
Journal:  J Leukoc Biol       Date:  2012-06-29       Impact factor: 4.962

3.  HLA-DRB1 the notorious gene in the mosaic of autoimmunity.

Authors:  María-Teresa Arango; Carlo Perricone; Shaye Kivity; Enrica Cipriano; Fulvia Ceccarelli; Guido Valesini; Yehuda Shoenfeld
Journal:  Immunol Res       Date:  2017-02       Impact factor: 2.829

Review 4.  Contribution of B-1a cells to systemic lupus erythematosus in the NZM2410 mouse model.

Authors:  Zhiwei Xu; Laurence Morel
Journal:  Ann N Y Acad Sci       Date:  2015-02-26       Impact factor: 5.691

5.  Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease.

Authors:  Alevtina Gall; Piper Treuting; Keith B Elkon; Yueh-Ming Loo; Michael Gale; Glen N Barber; Daniel B Stetson
Journal:  Immunity       Date:  2012-01-27       Impact factor: 31.745

Review 6.  Genetic regulation of serum cytokines in systemic lupus erythematosus.

Authors:  Silvia N Kariuki; Timothy B Niewold
Journal:  Transl Res       Date:  2009-09-25       Impact factor: 7.012

Review 7.  DNA methylation alterations in the pathogenesis of lupus.

Authors:  S H Chen; Q L Lv; L Hu; M J Peng; G H Wang; B Sun
Journal:  Clin Exp Immunol       Date:  2016-11-01       Impact factor: 4.330

8.  IFN regulatory factor 5 is required for disease development in the FcgammaRIIB-/-Yaa and FcgammaRIIB-/- mouse models of systemic lupus erythematosus.

Authors:  Christophe Richez; Kei Yasuda; Ramon G Bonegio; Amanda A Watkins; Tamar Aprahamian; Patricia Busto; Rocco J Richards; Chih Long Liu; Regina Cheung; Paul J Utz; Ann Marshak-Rothstein; Ian R Rifkin
Journal:  J Immunol       Date:  2009-12-09       Impact factor: 5.422

9.  A single-nucleotide polymorphism of the TNFSF4 gene is associated with systemic lupus erythematosus in Chinese Han population.

Authors:  Sheng-Quan Zhang; Jian-Wen Han; Liang-Dan Sun; Wen-Sheng Lu; Xian-Yong Yin; Xue-Jun Zhang; Sen Yang
Journal:  Rheumatol Int       Date:  2009-12-13       Impact factor: 2.631

10.  Combined analysis of genome-wide-linked susceptibility loci to Kawasaki disease in Han Chinese.

Authors:  Yuanlong Yan; Yongyi Ma; Yunqiang Liu; Hongde Hu; Ying Shen; Sizhong Zhang; Yongxing Ma; Dachang Tao; Qing Wu; Qian Peng; Yuan Yang
Journal:  Hum Genet       Date:  2013-03-01       Impact factor: 4.132
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