Literature DB >> 19165919

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus.

Stacy L Musone1, Kimberly E Taylor, Timothy T Lu, Joanne Nititham, Ricardo C Ferreira, Ward Ortmann, Nataliya Shifrin, Michelle A Petri, M Ilyas Kamboh, Susan Manzi, Michael F Seldin, Peter K Gregersen, Timothy W Behrens, Averil Ma, Pui-Yan Kwok, Lindsey A Criswell.   

Abstract

The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation. We show that three independent SNPs in the TNFAIP3 region (rs13192841, rs2230926 and rs6922466) are associated with systemic lupus erythematosus (SLE) among individuals of European ancestry. These findings provide critical links between A20 and the etiology of SLE.

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Year:  2008        PMID： 19165919      PMCID： PMC3897246          DOI： 10.1038/ng.202

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  10 in total

1.  Haploview: analysis and visualization of LD and haplotype maps.

Authors:  J C Barrett; B Fry; J Maller; M J Daly
Journal:  Bioinformatics       Date:  2004-08-05       Impact factor: 6.937

2.  Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Authors:  Robert M Plenge; Chris Cotsapas; Leela Davies; Alkes L Price; Paul I W de Bakker; Julian Maller; Itsik Pe'er; Noel P Burtt; Brendan Blumenstiel; Matt DeFelice; Melissa Parkin; Rachel Barry; Wendy Winslow; Claire Healy; Robert R Graham; Benjamin M Neale; Elena Izmailova; Ronenn Roubenoff; Alexander N Parker; Roberta Glass; Elizabeth W Karlson; Nancy Maher; David A Hafler; David M Lee; Michael F Seldin; Elaine F Remmers; Annette T Lee; Leonid Padyukov; Lars Alfredsson; Jonathan Coblyn; Michael E Weinblatt; Stacey B Gabriel; Shaun Purcell; Lars Klareskog; Peter K Gregersen; Nancy A Shadick; Mark J Daly; David Altshuler
Journal:  Nat Genet       Date:  2007-11-04       Impact factor: 38.330

3.  Collaboration, genetic associations, and lupus erythematosus.

Authors:  Mary K Crow
Journal:  N Engl J Med       Date:  2008-01-20       Impact factor: 91.245

4.  Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice.

Authors:  E G Lee; D L Boone; S Chai; S L Libby; M Chien; J P Lodolce; A Ma
Journal:  Science       Date:  2000-09-29       Impact factor: 47.728

5.  The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses.

Authors:  David L Boone; Emre E Turer; Eric G Lee; Regina-Celeste Ahmad; Matthew T Wheeler; Colleen Tsui; Paula Hurley; Marcia Chien; Sophia Chai; Osamu Hitotsumatsu; Elizabeth McNally; Cecile Pickart; Averil Ma
Journal:  Nat Immunol       Date:  2004-08-29       Impact factor: 25.606

6.  De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling.

Authors:  Ingrid E Wertz; Karen M O'Rourke; Honglin Zhou; Michael Eby; L Aravind; Somasekar Seshagiri; Ping Wu; Christian Wiesmann; Rohan Baker; David L Boone; Averil Ma; Eugene V Koonin; Vishva M Dixit
Journal:  Nature       Date:  2004-07-18       Impact factor: 49.962

7.  Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX.

Authors:  Geoffrey Hom; Robert R Graham; Barmak Modrek; Kimberly E Taylor; Ward Ortmann; Sophie Garnier; Annette T Lee; Sharon A Chung; Ricardo C Ferreira; P V Krishna Pant; Dennis G Ballinger; Roman Kosoy; F Yesim Demirci; M Ilyas Kamboh; Amy H Kao; Chao Tian; Iva Gunnarsson; Anders A Bengtsson; Solbritt Rantapää-Dahlqvist; Michelle Petri; Susan Manzi; Michael F Seldin; Lars Rönnblom; Ann-Christine Syvänen; Lindsey A Criswell; Peter K Gregersen; Timothy W Behrens
Journal:  N Engl J Med       Date:  2008-01-20       Impact factor: 91.245

8.  The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals.

Authors:  Osamu Hitotsumatsu; Regina-Celeste Ahmad; Rita Tavares; Min Wang; Dana Philpott; Emre E Turer; Bettina L Lee; Nataliya Shiffin; Rommel Advincula; Barbara A Malynn; Catherine Werts; Averil Ma
Journal:  Immunity       Date:  2008-03       Impact factor: 31.745

9.  Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Authors:  Robert R Graham; Chris Cotsapas; Leela Davies; Rachel Hackett; Christopher J Lessard; Joanlise M Leon; Noel P Burtt; Candace Guiducci; Melissa Parkin; Casey Gates; Robert M Plenge; Timothy W Behrens; Joan E Wither; John D Rioux; Paul R Fortin; Deborah Cunninghame Graham; Andrew K Wong; Timothy J Vyse; Mark J Daly; David Altshuler; Kathy L Moser; Patrick M Gaffney
Journal:  Nat Genet       Date:  2008-09       Impact factor: 38.330

10.  Rheumatoid arthritis association at 6q23.

Authors:  Wendy Thomson; Anne Barton; Xiayi Ke; Steve Eyre; Anne Hinks; John Bowes; Rachelle Donn; Deborah Symmons; Samantha Hider; Ian N Bruce; Anthony G Wilson; Ioanna Marinou; Ann Morgan; Paul Emery; Angela Carter; Sophia Steer; Lynne Hocking; David M Reid; Paul Wordsworth; Pille Harrison; David Strachan; Jane Worthington
Journal:  Nat Genet       Date:  2007-11-04       Impact factor: 38.330
  10 in total
  215 in total

1.  Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

Authors:  Young Ho Lee; Sang-Cheol Bae; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song
Journal:  Inflamm Res       Date:  2012-03-09       Impact factor: 4.575

Review 2.  What have genome-wide studies told us about psoriatic arthritis?

Authors:  James Bluett; Anne Barton
Journal:  Curr Rheumatol Rep       Date:  2012-08       Impact factor: 4.592

Review 3.  Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

Authors:  Samuel E Vaughn; Leah C Kottyan; Melissa E Munroe; John B Harley
Journal:  J Leukoc Biol       Date:  2012-06-29       Impact factor: 4.962

Review 4.  Signaling to NF-kappaB: regulation by ubiquitination.

Authors:  Ingrid E Wertz; Vishva M Dixit
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-03       Impact factor: 10.005

5.  Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.

Authors:  Paula S Ramos; Elisabeth E Brown; Robert P Kimberly; Carl D Langefeld
Journal:  Semin Nephrol       Date:  2010-03       Impact factor: 5.299

6.  A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

Authors:  Y Saitoh; A Hamano; K Mochida; A Kakeya; M Uno; E Tsuruyama; H Ichikawa; F Tokunaga; A Utsunomiya; T Watanabe; S Yamaoka
Journal:  Leukemia       Date:  2015-10-06       Impact factor: 11.528

7.  Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20.

Authors:  M Sisto; A Barca; D D Lofrumento; S Lisi
Journal:  Clin Exp Immunol       Date:  2016-02-23       Impact factor: 4.330

Review 8.  Negative regulation of TLR signaling in myeloid cells--implications for autoimmune diseases.

Authors:  Jessica A Hamerman; Jessica Pottle; Minjian Ni; Yantao He; Zhong-Yin Zhang; Jane H Buckner
Journal:  Immunol Rev       Date:  2016-01       Impact factor: 12.988

9.  C/EBP β mRNA expression is upregulated and positively correlated with the expression of TNIP1/TNFAIP3 in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.

Authors:  Tian Qian; Yan Chen; Xiaowei Shi; Jian Li; Fei Hao; Dongmei Zhang
Journal:  Exp Ther Med       Date:  2016-08-23       Impact factor: 2.447

10.  A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.

Authors:  Yongzhe Li; Kunlin Zhang; Hua Chen; Fei Sun; Juanjuan Xu; Ziyan Wu; Ping Li; Liuyan Zhang; Yang Du; Haixia Luan; Xi Li; Lijun Wu; Hongbin Li; Huaxiang Wu; Xiangpei Li; Xiaomei Li; Xiao Zhang; Lu Gong; Lie Dai; Lingyun Sun; Xiaoxia Zuo; Jianhua Xu; Huiping Gong; Zhijun Li; Shengquan Tong; Min Wu; Xiaofeng Li; Weiguo Xiao; Guochun Wang; Ping Zhu; Min Shen; Shengyun Liu; Dongbao Zhao; Wei Liu; Yi Wang; Cibo Huang; Quan Jiang; Guijian Liu; Bin Liu; Shaoxian Hu; Wen Zhang; Zhuoli Zhang; Xin You; Mengtao Li; Weixin Hao; Cheng Zhao; Xiaomei Leng; Liqi Bi; Yongfu Wang; Fengxiao Zhang; Qun Shi; Wencheng Qi; Xuewu Zhang; Yuan Jia; Jinmei Su; Qin Li; Yong Hou; Qingjun Wu; Dong Xu; Wenjie Zheng; Miaojia Zhang; Qian Wang; Yunyun Fei; Xuan Zhang; Jing Li; Ying Jiang; Xinping Tian; Lidan Zhao; Li Wang; Bin Zhou; Yang Li; Yan Zhao; Xiaofeng Zeng; Jurg Ott; Jing Wang; Fengchun Zhang
Journal:  Nat Genet       Date:  2013-10-06       Impact factor: 38.330
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