| Literature DB >> 18204448 |
Swapan K Nath1, Shizhong Han, Xana Kim-Howard, Jennifer A Kelly, Parvathi Viswanathan, Gary S Gilkeson, Wei Chen, Cheng Zhu, Rodger P McEver, Robert P Kimberly, Marta E Alarcón-Riquelme, Timothy J Vyse, Quan-Zhen Li, Edward K Wakeland, Joan T Merrill, Judith A James, Kenneth M Kaufman, Joel M Guthridge, John B Harley.
Abstract
We identified and replicated an association between ITGAM (CD11b) at 16p11.2 and risk of systemic lupus erythematosus (SLE) in 3,818 individuals of European descent. The strongest association was at a nonsynonymous SNP, rs1143679 (P = 1.7 x 10(-17), odds ratio = 1.78). We further replicated this association in two independent samples of individuals of African descent (P = 0.0002 and 0.003; overall meta-analysis P = 6.9 x 10(-22)). The genetic association between ITGAM and SLE implicates the alpha(M)beta2-integrin adhesion pathway in disease development.Entities:
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Year: 2008 PMID： 18204448 DOI： 10.1038/ng.71
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330