Literature DB >> 19165918

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.

Robert R Graham1, Chris Cotsapas, Leela Davies, Rachel Hackett, Christopher J Lessard, Joanlise M Leon, Noel P Burtt, Candace Guiducci, Melissa Parkin, Casey Gates, Robert M Plenge, Timothy W Behrens, Joan E Wither, John D Rioux, Paul R Fortin, Deborah Cunninghame Graham, Andrew K Wong, Timothy J Vyse, Mark J Daly, David Altshuler, Kathy L Moser, Patrick M Gaffney.   

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.

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Year:  2008        PMID： 19165918      PMCID： PMC2772171          DOI： 10.1038/ng.200

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  12 in total

1.  Two independent alleles at 6q23 associated with risk of rheumatoid arthritis.

Authors:  Robert M Plenge; Chris Cotsapas; Leela Davies; Alkes L Price; Paul I W de Bakker; Julian Maller; Itsik Pe'er; Noel P Burtt; Brendan Blumenstiel; Matt DeFelice; Melissa Parkin; Rachel Barry; Wendy Winslow; Claire Healy; Robert R Graham; Benjamin M Neale; Elena Izmailova; Ronenn Roubenoff; Alexander N Parker; Roberta Glass; Elizabeth W Karlson; Nancy Maher; David A Hafler; David M Lee; Michael F Seldin; Elaine F Remmers; Annette T Lee; Leonid Padyukov; Lars Alfredsson; Jonathan Coblyn; Michael E Weinblatt; Stacey B Gabriel; Shaun Purcell; Lars Klareskog; Peter K Gregersen; Nancy A Shadick; Mark J Daly; David Altshuler
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Journal:  N Engl J Med       Date:  2008-01-20       Impact factor: 91.245

6.  Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci.

Authors:  John B Harley; Marta E Alarcón-Riquelme; Lindsey A Criswell; Chaim O Jacob; Robert P Kimberly; Kathy L Moser; Betty P Tsao; Timothy J Vyse; Carl D Langefeld; Swapan K Nath; Joel M Guthridge; Beth L Cobb; Daniel B Mirel; Miranda C Marion; Adrienne H Williams; Jasmin Divers; Wei Wang; Summer G Frank; Bahram Namjou; Stacey B Gabriel; Annette T Lee; Peter K Gregersen; Timothy W Behrens; Kimberly E Taylor; Michelle Fernando; Raphael Zidovetzki; Patrick M Gaffney; Jeffrey C Edberg; John D Rioux; Joshua O Ojwang; Judith A James; Joan T Merrill; Gary S Gilkeson; Michael F Seldin; Hong Yin; Emily C Baechler; Quan-Zhen Li; Edward K Wakeland; Gail R Bruner; Kenneth M Kaufman; Jennifer A Kelly
Journal:  Nat Genet       Date:  2008-01-20       Impact factor: 38.330

7.  Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus.

Authors:  Sergey V Kozyrev; Anna-Karin Abelson; Jerome Wojcik; Ammar Zaghlool; M V Prasad Linga Reddy; Elena Sanchez; Iva Gunnarsson; Elisabet Svenungsson; Gunnar Sturfelt; Andreas Jönsen; Lennart Truedsson; Bernardo A Pons-Estel; Torsten Witte; Sandra D'Alfonso; Nadia Barizzone; Nadia Barrizzone; Maria Giovanna Danieli; Carmen Gutierrez; Ana Suarez; Peter Junker; Helle Laustrup; Maria Francisca González-Escribano; Javier Martin; Hadi Abderrahim; Marta E Alarcón-Riquelme
Journal:  Nat Genet       Date:  2008-01-20       Impact factor: 38.330

8.  Age, sex, and race effects on mortality from systemic lupus erythematosus in the United States.

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Journal:  Arthritis Rheum       Date:  1978-05

9.  Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part I.

Authors:  Charles G Helmick; David T Felson; Reva C Lawrence; Sherine Gabriel; Rosemarie Hirsch; C Kent Kwoh; Matthew H Liang; Hilal Maradit Kremers; Maureen D Mayes; Peter A Merkel; Stanley R Pillemer; John D Reveille; John H Stone
Journal:  Arthritis Rheum       Date:  2008-01

10.  The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.

Authors:  K Heyninck; R Beyaert
Journal:  FEBS Lett       Date:  1999-01-15       Impact factor: 4.124
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2.  Associations between TNFAIP3 gene polymorphisms and rheumatoid arthritis: a meta-analysis.

Authors:  Young Ho Lee; Sang-Cheol Bae; Sung Jae Choi; Jong Dae Ji; Gwan Gyu Song
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Review 3.  Genetic susceptibility to lupus: the biological basis of genetic risk found in B cell signaling pathways.

Authors:  Samuel E Vaughn; Leah C Kottyan; Melissa E Munroe; John B Harley
Journal:  J Leukoc Biol       Date:  2012-06-29       Impact factor: 4.962

4.  Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis.

Authors:  Paula S Ramos; Elisabeth E Brown; Robert P Kimberly; Carl D Langefeld
Journal:  Semin Nephrol       Date:  2010-03       Impact factor: 5.299

Review 5.  Genome-wide significant associations for variants with minor allele frequency of 5% or less--an overview: A HuGE review.

Authors:  Orestis A Panagiotou; Evangelos Evangelou; John P A Ioannidis
Journal:  Am J Epidemiol       Date:  2010-09-28       Impact factor: 4.897

6.  A20 targets caspase-8 and FADD to protect HTLV-I-infected cells.

Authors:  Y Saitoh; A Hamano; K Mochida; A Kakeya; M Uno; E Tsuruyama; H Ichikawa; F Tokunaga; A Utsunomiya; T Watanabe; S Yamaoka
Journal:  Leukemia       Date:  2015-10-06       Impact factor: 11.528

7.  Downstream activation of NF-κB in the EDA-A1/EDAR signalling in Sjögren's syndrome and its regulation by the ubiquitin-editing enzyme A20.

Authors:  M Sisto; A Barca; D D Lofrumento; S Lisi
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8.  C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.

Authors:  Yemil Atisha-Fregoso; Guadalupe Lima; Eduardo Carrillo-Maravilla; Rosalinda Posadas-Sánchez; Nonanzit Pérez-Hernández; Miguel Baños-Peláez; Alejandra Iturralde-Chávez; Nora Hernández-Díaz; Juan Jakez-Ocampo; José Manuel Rodríguez-Pérez; Gilberto Vargas-Alarcón; Luis Llorente; Juanita Romero-Díaz
Journal:  Clin Rheumatol       Date:  2018-03-20       Impact factor: 2.980

9.  A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23.

Authors:  Yongzhe Li; Kunlin Zhang; Hua Chen; Fei Sun; Juanjuan Xu; Ziyan Wu; Ping Li; Liuyan Zhang; Yang Du; Haixia Luan; Xi Li; Lijun Wu; Hongbin Li; Huaxiang Wu; Xiangpei Li; Xiaomei Li; Xiao Zhang; Lu Gong; Lie Dai; Lingyun Sun; Xiaoxia Zuo; Jianhua Xu; Huiping Gong; Zhijun Li; Shengquan Tong; Min Wu; Xiaofeng Li; Weiguo Xiao; Guochun Wang; Ping Zhu; Min Shen; Shengyun Liu; Dongbao Zhao; Wei Liu; Yi Wang; Cibo Huang; Quan Jiang; Guijian Liu; Bin Liu; Shaoxian Hu; Wen Zhang; Zhuoli Zhang; Xin You; Mengtao Li; Weixin Hao; Cheng Zhao; Xiaomei Leng; Liqi Bi; Yongfu Wang; Fengxiao Zhang; Qun Shi; Wencheng Qi; Xuewu Zhang; Yuan Jia; Jinmei Su; Qin Li; Yong Hou; Qingjun Wu; Dong Xu; Wenjie Zheng; Miaojia Zhang; Qian Wang; Yunyun Fei; Xuan Zhang; Jing Li; Ying Jiang; Xinping Tian; Lidan Zhao; Li Wang; Bin Zhou; Yang Li; Yan Zhao; Xiaofeng Zeng; Jurg Ott; Jing Wang; Fengchun Zhang
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Review 10.  Recent insights into the genetic basis of systemic lupus erythematosus.

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