OBJECTIVES: Late-life depression (LLD) is associated with persistent cognitive impairment in a subset of individuals. The purpose of this study was to 1) examine the frequency and characteristics of cognitive diagnoses (Mild Cognitive Impairment [MCI], dementia) among remitted elderly depressed subjects and 2) to compare the prevalence rate and correlates of cognitive diagnoses with those of comparison subjects. DESIGN: Crosssectional. SETTING: Outpatient geriatric mental health clinic. PARTICIPANTS: The authors examined cognitive diagnoses among 109 subjects age 65 and older, after depression treatment response and 65 never-depressed, age- and education-equated comparison subjects. MEASUREMENTS: Cognitive diagnoses were independently established by the University of Pittsburgh's Alzheimer's Disease Research Center. Bivariate and multivariate analyses were conducted to examine the role of specific risk factors for cognitive diagnosis among depressed subjects. RESULTS: Relative to comparison subjects, nearly twice as many depressed subjects were diagnosed with MCI or dementia (48% versus 28%). Of the 109 depressed subjects, 38% were diagnosed with MCI (63% amnestic, 37% nonamnestic). The majority of amnestic MCI subjects (85%) had the multiple domain subtype. Age, but not age of onset or lifetime depression duration, predicted cognitive diagnosis. CONCLUSIONS: Despite adequate depression treatment response, 48% of remitted depressed subjects had a cognitive diagnosis. Of the 38% diagnosed with MCI, there was high representation among both the amnestic and the nonamnestic subtypes, suggesting heterogeneity in cognitive course and outcomes in LLD.
OBJECTIVES: Late-life depression (LLD) is associated with persistent cognitive impairment in a subset of individuals. The purpose of this study was to 1) examine the frequency and characteristics of cognitive diagnoses (Mild Cognitive Impairment [MCI], dementia) among remitted elderly depressed subjects and 2) to compare the prevalence rate and correlates of cognitive diagnoses with those of comparison subjects. DESIGN: Crosssectional. SETTING:Outpatient geriatric mental health clinic. PARTICIPANTS: The authors examined cognitive diagnoses among 109 subjects age 65 and older, after depression treatment response and 65 never-depressed, age- and education-equated comparison subjects. MEASUREMENTS: Cognitive diagnoses were independently established by the University of Pittsburgh's Alzheimer's Disease Research Center. Bivariate and multivariate analyses were conducted to examine the role of specific risk factors for cognitive diagnosis among depressed subjects. RESULTS: Relative to comparison subjects, nearly twice as many depressed subjects were diagnosed with MCI or dementia (48% versus 28%). Of the 109 depressed subjects, 38% were diagnosed with MCI (63% amnestic, 37% nonamnestic). The majority of amnestic MCI subjects (85%) had the multiple domain subtype. Age, but not age of onset or lifetime depression duration, predicted cognitive diagnosis. CONCLUSIONS: Despite adequate depression treatment response, 48% of remitted depressed subjects had a cognitive diagnosis. Of the 38% diagnosed with MCI, there was high representation among both the amnestic and the nonamnestic subtypes, suggesting heterogeneity in cognitive course and outcomes in LLD.
Authors: Robert C Green; L Adrienne Cupples; Alex Kurz; Sanford Auerbach; Rodney Go; Dessa Sadovnick; Ranjan Duara; Walter A Kukull; Helena Chui; Timi Edeki; Patrick A Griffith; Robert P Friedland; David Bachman; Lindsay Farrer Journal: Arch Neurol Date: 2003-05
Authors: Constantine G Lyketsos; Oscar Lopez; Beverly Jones; Annette L Fitzpatrick; John Breitner; Steven DeKosky Journal: JAMA Date: 2002-09-25 Impact factor: 56.272
Authors: Robert D Nebes; Bruce G Pollock; Patricia R Houck; Meryl A Butters; Benoit H Mulsant; Michelle D Zmuda; Charles F Reynolds Journal: J Psychiatr Res Date: 2003 Mar-Apr Impact factor: 4.791
Authors: Oscar L Lopez; William J Jagust; Steven T DeKosky; James T Becker; Annette Fitzpatrick; Corinne Dulberg; John Breitner; Constantine Lyketsos; Beverly Jones; Claudia Kawas; Michelle Carlson; Lewis H Kuller Journal: Arch Neurol Date: 2003-10
Authors: Meryl A Butters; Ellen M Whyte; Robert D Nebes; Amy E Begley; Mary Amanda Dew; Benoit H Mulsant; Michelle D Zmuda; Rishi Bhalla; Carolyn Cidis Meltzer; Bruce G Pollock; Charles F Reynolds; James T Becker Journal: Arch Gen Psychiatry Date: 2004-06
Authors: Meryl A Butters; Jeffrey B Young; Oscar Lopez; Howard J Aizenstein; Benoit H Mulsant; Charles F Reynolds; Steven T DeKosky; James T Becker Journal: Dialogues Clin Neurosci Date: 2008 Impact factor: 5.986
Authors: Joan C Rogers; Margo B Holm; Ketki D Raina; Mary Amanda Dew; Min-Mei Shih; Amy Begley; Patricia R Houck; Sati Mazumdar; Charles F Reynolds Journal: Psychiatry Res Date: 2010-08-15 Impact factor: 3.222
Authors: Charles F Reynolds; Meryl A Butters; Oscar Lopez; Bruce G Pollock; Mary Amanda Dew; Benoit H Mulsant; Eric J Lenze; Margo Holm; Joan C Rogers; Sati Mazumdar; Patricia R Houck; Amy Begley; Stewart Anderson; Jordan F Karp; Mark D Miller; Ellen M Whyte; Jacqueline Stack; Ariel Gildengers; Katalin Szanto; Salem Bensasi; Daniel I Kaufer; M Ilyas Kamboh; Steven T DeKosky Journal: Arch Gen Psychiatry Date: 2011-01
Authors: Joseph S Goveas; Patricia E Hogan; Jane M Kotchen; Jordan W Smoller; Natalie L Denburg; JoAnn E Manson; Aruna Tummala; W Jerry Mysiw; Judith K Ockene; Nancy F Woods; Mark A Espeland; Sylvia Wassertheil-Smoller Journal: Int Psychogeriatr Date: 2012-02-03 Impact factor: 3.878
Authors: Wenjun Li; B Douglas Ward; Chunming Xie; Jennifer L Jones; Piero G Antuono; Shi-Jiang Li; Joseph S Goveas Journal: J Psychiatr Res Date: 2015-09-09 Impact factor: 4.791
Authors: Adam P Spira; George W Rebok; Katie L Stone; Joel H Kramer; Kristine Yaffe Journal: Am J Geriatr Psychiatry Date: 2012-12 Impact factor: 4.105
Authors: Joseph S Goveas; Mark A Espeland; Patricia E Hogan; Hilary A Tindle; Regina A Shih; Jane M Kotchen; Jennifer G Robinson; Deborah E Barnes; Susan M Resnick Journal: J Geriatr Psychiatry Neurol Date: 2014-02-28 Impact factor: 2.680
Authors: A G Gildengers; D Chisholm; M A Butters; S J Anderson; A Begley; M Holm; J C Rogers; C F Reynolds; B H Mulsant Journal: Psychol Med Date: 2012-07-30 Impact factor: 7.723
Authors: Chunming Xie; Wenjun Li; Gang Chen; B Douglas Ward; Malgorzata B Franczak; Jennifer L Jones; Piero G Antuono; Shi-Jiang Li; Joseph S Goveas Journal: Behav Brain Res Date: 2012-08-14 Impact factor: 3.332