Christopher F Murphy1, George S Alexopoulos. 1. Weill Medical College of Cornell University, 21 Bloomingdale Road, White Plains, NY 10605, USA. galexop@med.cornell.edu
Abstract
OBJECTIVE: Many older adults with major depression (MDD) present with impairment in initiation and perseveration (IP) tests. However, it remains unclear how these abnormalities change during the course of depression. METHODS: The authors studied the longitudinal covariation of depression severity and IP functioning in 157 depressed older adults with MDD. Patients with and without baseline IP impairment were studied on three occasions over 1 year. RESULTS: Depression severity was associated with concurrent IP scores; however, despite IP improvement, those with impaired baseline IP functioning did not reach the level of their non-impaired counterparts. CONCLUSION: The persistence of IP abnormalities suggests that these patients require careful treatment planning and follow-up, given that earlier studies noted an association of abnormal IP with disability and poor outcomes of depression treatment.
OBJECTIVE: Many older adults with major depression (MDD) present with impairment in initiation and perseveration (IP) tests. However, it remains unclear how these abnormalities change during the course of depression. METHODS: The authors studied the longitudinal covariation of depression severity and IP functioning in 157 depressed older adults with MDD. Patients with and without baseline IP impairment were studied on three occasions over 1 year. RESULTS:Depression severity was associated with concurrent IP scores; however, despite IP improvement, those with impaired baseline IP functioning did not reach the level of their non-impaired counterparts. CONCLUSION: The persistence of IP abnormalities suggests that these patients require careful treatment planning and follow-up, given that earlier studies noted an association of abnormal IP with disability and poor outcomes of depression treatment.
Authors: Paul B Rosenberg; Michelle M Mielke; Brian Appleby; Esther Oh; Jeannie-Marie Leoutsakos; Constantine G Lyketsos Journal: Int J Geriatr Psychiatry Date: 2010-09-15 Impact factor: 3.485
Authors: Monique A Pimontel; David Rindskopf; Bret R Rutherford; Patrick J Brown; Steven P Roose; Joel R Sneed Journal: Am J Geriatr Psychiatry Date: 2015-05-21 Impact factor: 4.105
Authors: Matthew J Hoptman; Faith M Gunning-Dixon; Christopher F Murphy; Babak A Ardekani; Jan Hrabe; Kelvin O Lim; Glenda R Etwaroo; Dora Kanellopoulos; George S Alexopoulos Journal: J Affect Disord Date: 2008-09-20 Impact factor: 4.839
Authors: Jason A Gandelman; Hakmook Kang; Ashleigh Antal; Kimberly Albert; Brian D Boyd; Alexander C Conley; Paul Newhouse; Warren D Taylor Journal: J Clin Psychiatry Date: 2018-08-28 Impact factor: 4.384
Authors: Maria C Duggan; Li Wang; Jo Ellen Wilson; Robert S Dittus; E Wesley Ely; James C Jackson Journal: J Crit Care Date: 2016-08-31 Impact factor: 3.425
Authors: Meryl A Butters; Jeffrey B Young; Oscar Lopez; Howard J Aizenstein; Benoit H Mulsant; Charles F Reynolds; Steven T DeKosky; James T Becker Journal: Dialogues Clin Neurosci Date: 2008 Impact factor: 5.986