Literature DB >> 1929266

Susceptibility of Pneumocystis carinii to artemisinin in vitro.

S Merali1, S R Meshnick.   

Abstract

The susceptibility of Pneumocystis carinii to artemisinin (qinghaosu) was determined in short-term primary culture. In untreated cultures, trophozoites increased an average of fivefold over 4 days. Inhibition of parasite growth in cultures treated with artemisinin at concentrations as low as 0.5 microM was seen. In contrast, artemisinin concentrations up to 100 microM had no effect on feeder layer cells.

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Year:  1991        PMID： 1929266      PMCID： PMC284315          DOI： 10.1128/AAC.35.6.1225

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  In vitro studies of Pneumocystis carinii.

Authors:  M T Cushion
Journal:  J Protozool       Date:  1989 Jan-Feb

2.  Propagation and purification of rat Pneumocystis carinii in short-term cell culture.

Authors:  M Y Armstrong; F F Richards
Journal:  J Protozool       Date:  1989 Jan-Feb

3.  Activated oxygen mediates the antimalarial activity of qinghaosu.

Authors:  S R Meshnick; T W Tsang; F B Lin; H Z Pan; C N Chang; F Kuypers; D Chiu; B Lubin
Journal:  Prog Clin Biol Res       Date:  1989

4.  Clinical studies of treatment of falciparum malaria with artemether, a derivative of qinghaosu.

Authors:  T Y Wang; R C Xu
Journal:  J Tradit Chin Med       Date:  1985-12       Impact factor: 0.848

5.  Antimicrobial susceptibility of Pneumocystis carinii in culture.

Authors:  M S Bartlett; R Eichholtz; J W Smith
Journal:  Diagn Microbiol Infect Dis       Date:  1985-09       Impact factor: 2.803

6.  A randomized comparative study of artemisinine (qinghaosu) suppositories and oral quinine in acute falciparum malaria.

Authors:  K Arnold; T H Tran; T C Nguyen; H P Nguyen; P Pham
Journal:  Trans R Soc Trop Med Hyg       Date:  1990 Jul-Aug       Impact factor: 2.184

Review 7.  Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.

Authors:  R T Davey; H Masur
Journal:  Antimicrob Agents Chemother       Date:  1990-04       Impact factor: 5.191

Review 8.  The chemistry, pharmacology, and clinical applications of qinghaosu (artemisinin) and its derivatives.

Authors:  X D Luo; C C Shen
Journal:  Med Res Rev       Date:  1987 Jan-Mar       Impact factor: 12.944

Review 9.  Pneumocystis carinii pneumonia: diagnosis.

Authors:  P C Hopewell
Journal:  J Infect Dis       Date:  1988-06       Impact factor: 5.226

10.  Advantages of a modified toluidine blue O stain and bronchoalveolar lavage for the diagnosis of Pneumocystis carinii pneumonia.

Authors:  L L Gosey; R M Howard; F G Witebsky; F P Ognibene; T C Wu; V J Gill; J D MacLowry
Journal:  J Clin Microbiol       Date:  1985-11       Impact factor: 5.948
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  12 in total

1.  In vitro pharmacodynamic parameters of sordarin derivatives in comparison with those of marketed compounds against Pneumocystis carinii isolated from rats.

Authors:  P Aviles; E M Aliouat; A Martinez; E Dei-Cas; E Herreros; L Dujardin; D Gargallo-Viola
Journal:  Antimicrob Agents Chemother       Date:  2000-05       Impact factor: 5.191

Review 2.  Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.

Authors:  S R Meshnick; T E Taylor; S Kamchonwongpaisan
Journal:  Microbiol Rev       Date:  1996-06

Review 3.  Recent advances in artemisinin production through heterologous expression.

Authors:  Patrick R Arsenault; Kristin K Wobbe; Pamela J Weathers
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

4.  DMSO triggers the generation of ROS leading to an increase in artemisinin and dihydroartemisinic acid in Artemisia annua shoot cultures.

Authors:  Abdul Mannan; Chunzhao Liu; Patrick R Arsenault; Melissa J Towler; Dan R Vail; Argelia Lorence; Pamela J Weathers
Journal:  Plant Cell Rep       Date:  2009-12-20       Impact factor: 4.570

5.  Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium.

Authors:  L C Chio; L A Bolyard; M Nasr; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1996-03       Impact factor: 5.191

6.  Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase.

Authors:  A Rosowsky; J B Hynes; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1995-01       Impact factor: 5.191

7.  Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii.

Authors:  C Atzori; A Bruno; G Chichino; E Bombardelli; M Scaglia; M Ghione
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

8.  Evaluation of potent inhibitors of dihydrofolate reductase in a culture model for growth of Pneumocystis carinii.

Authors:  M S Bartlett; M Shaw; P Navaran; J W Smith; S F Queener
Journal:  Antimicrob Agents Chemother       Date:  1995-11       Impact factor: 5.191

9.  Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160).

Authors:  Marcel Kaiser; Sergio Wittlin; Angela Nehrbass-Stuedli; Yuxiang Dong; Xiaofang Wang; Andrew Hemphill; Hugues Matile; Reto Brun; Jonathan L Vennerstrom
Journal:  Antimicrob Agents Chemother       Date:  2007-06-11       Impact factor: 5.191

Review 10.  Artemisinins: their growing importance in medicine.

Authors:  Sanjeev Krishna; Leyla Bustamante; Richard K Haynes; Henry M Staines
Journal:  Trends Pharmacol Sci       Date:  2008-08-25       Impact factor: 14.819
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