| Literature DB >> 8801435 |
S R Meshnick1, T E Taylor, S Kamchonwongpaisan.
Abstract
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.Entities:
Mesh：
Substances：
Year: 1996 PMID： 8801435 PMCID： PMC239445 DOI： 10.1128/mr.60.2.301-315.1996
Source DB: PubMed Journal: Microbiol Rev ISSN： 0146-0749