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Literature DB >> 19289531

In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.

Ayrton S Cavalheiro¹, Grazieli Maboni, Maria I de Azevedo, Juliana S Argenta, Daniela I B Pereira, Tatiana B Spader, Sydney H Alves, Janio M Santurio.

Abstract

In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.

Entities: Chemical Species

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Year: 2009 PMID： 19289531 PMCID： PMC2681559 DOI： 10.1128/AAC.01506-08

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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3. Antifungal combinations.

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Journal: Methods Mol Med Date: 2005

4. In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.

Authors: Juliana S Argenta; Janio M Santurio; Sydney H Alves; Daniela I B Pereira; Ayrton S Cavalheiro; Andréia Spanamberg; Laerte Ferreiro
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6. Development of a nested polymerase chain reaction assay for the detection and identification of Pythium insidiosum.

Authors: Amy M Grooters; Melaney K Gee
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7. A molecular phylogeny of Pythium insidiosum.

Authors: Andrew M Schurko; Leonel Mendoza; C André Lévesque; Nicole L Désaulniers; Arthur W A M de Cock; Glen R Klassen
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10. Caspofungin in vitro and in vivo activity against Brazilian Pythium insidiosum strains isolated from animals.

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2. In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum.

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Journal: Antimicrob Agents Chemother Date: 2014-07-07 Impact factor: 5.191

In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.

Review 1. Combinations of antifungal agents in therapy--what value are they?

Review 2. Combination antifungal therapy.

3. Antifungal combinations.

4. In vitro activities of voriconazole, itraconazole, and terbinafine alone or in combination against Pythium insidiosum isolates from Brazil.

5. Clinical and epidemiological analyses of human pythiosis in Thailand.

6. Development of a nested polymerase chain reaction assay for the detection and identification of Pythium insidiosum.

7. A molecular phylogeny of Pythium insidiosum.

Review 8. Human pythiosis in Thailand.

9. In vitro sensitivity of Penicillium marneffei and Pythium insidiosum to various antifungal agents.

10. Caspofungin in vitro and in vivo activity against Brazilian Pythium insidiosum strains isolated from animals.

1. Combat-Related Pythium aphanidermatum Invasive Wound Infection: Case Report and Discussion of Utility of Molecular Diagnostics.

2. In vitro synergism observed with azithromycin, clarithromycin, minocycline, or tigecycline in association with antifungal agents against Pythium insidiosum.

3. New insights into the in vitro susceptibility of Pythium insidiosum.

4. In Vitro Susceptibility of Thai Pythium insidiosum Isolates to Antibacterial Agents.

5. In vitro susceptibility of Brazilian Pythium insidiosum isolates to essential oils of some Lamiaceae family species.

6. Imported pythium insidiosum keratitis after a swim in Thailand by a contact lens-wearing traveler.

7. In vitro susceptibility of Pythium insidiosum to macrolides and tetracycline antibiotics.

Review 8. A Review: Antimicrobial Therapy for Human Pythiosis.

9. In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum.

10. Successful treatment of a child with vascular pythiosis.