Literature DB >> 27216049

In Vitro Synergism between Azithromycin or Terbinafine and Topical Antimicrobial Agents against Pythium insidiosum.

Sabrina R Itaqui1, Camila M Verdi1, Juliana S M Tondolo1, Thaisa S da Luz1, Sydney H Alves2, Janio M Santurio1, Érico S Loreto3.   

Abstract

We describe here in vitro activity for the combination of azithromycin or terbinafine and benzalkonium, cetrimide, cetylpyridinium, mupirocin, triclosan, or potassium permanganate. With the exception of potassium permanganate, the remaining antimicrobial drugs were active and had an MIC90 between 2 and 32 μg∕ml. The greatest synergism was observed for the combination of terbinafine and cetrimide (71.4%). In vivo experimental evaluations will clarify the potential of these drugs for the topical treatment of lesions caused by Pythium insidiosum.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27216049      PMCID： PMC4958184          DOI： 10.1128/AAC.00154-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

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Authors:  Francielli P K Jesus; Érico S Loreto; Laerte Ferreiro; Sydney H Alves; David Driemeier; Suyene O Souza; Raqueli T França; Sonia T A Lopes; Maiara B Pilotto; Aline Ludwig; Maria I Azevedo; Tatiana C Ribeiro; Juliana S M Tondolo; Janio M Santurio
Journal:  Antimicrob Agents Chemother       Date:  2015-10-12       Impact factor: 5.191
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