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Literature DB >> 19286664

Turning cancer stem cells inside out: an exploration of glioma stem cell signaling pathways.

Zhizhong Li¹, Hui Wang, Christine E Eyler, Anita B Hjelmeland, Jeremy N Rich.

Abstract

Tumors are complex collections of heterogeneous cells with recruited vasculature, inflammatory cells, and stromal elements. Neoplastic cells frequently display a hierarchy in differentiation status. Recent studies suggest that brain tumors have a limited population of neoplastic cells called cancer stem cells with the capacity for sustained self-renewal and tumor propagation. Brain tumor stem cells contribute to therapeutic resistance and tumor angiogenesis. In this minireview, we summarize recent data regarding critical signaling pathways involved in brain tumor stem cell biology and discuss how targeting these molecules may contribute to the development of novel anti-glioma therapies.

Entities: Disease

Mesh：

Substances：

Year: 2009 PMID： 19286664 PMCID： PMC2719304 DOI： 10.1074/jbc.R900013200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

54 in total

1. A perivascular niche for brain tumor stem cells.

Authors: Christopher Calabrese; Helen Poppleton; Mehmet Kocak; Twala L Hogg; Christine Fuller; Blair Hamner; Eun Young Oh; M Waleed Gaber; David Finklestein; Meredith Allen; Adrian Frank; Ildar T Bayazitov; Stanislav S Zakharenko; Amar Gajjar; Andrew Davidoff; Richard J Gilbertson
Journal: Cancer Cell Date: 2007-01 Impact factor: 31.743

2. AZD2171, a pan-VEGF receptor tyrosine kinase inhibitor, normalizes tumor vasculature and alleviates edema in glioblastoma patients.

Authors: Tracy T Batchelor; A Gregory Sorensen; Emmanuelle di Tomaso; Wei-Ting Zhang; Dan G Duda; Kenneth S Cohen; Kevin R Kozak; Daniel P Cahill; Poe-Jou Chen; Mingwang Zhu; Marek Ancukiewicz; Maciej M Mrugala; Scott Plotkin; Jan Drappatz; David N Louis; Percy Ivy; David T Scadden; Thomas Benner; Jay S Loeffler; Patrick Y Wen; Rakesh K Jain
Journal: Cancer Cell Date: 2007-01 Impact factor: 31.743

3. Notch signaling enhances nestin expression in gliomas.

Authors: Alan H Shih; Eric C Holland
Journal: Neoplasia Date: 2006-12 Impact factor: 5.715

4. HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity.

Authors: Virginie Clement; Pilar Sanchez; Nicolas de Tribolet; Ivan Radovanovic; Ariel Ruiz i Altaba
Journal: Curr Biol Date: 2006-12-28 Impact factor: 10.834

5. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

Authors: Shideng Bao; Qiulian Wu; Roger E McLendon; Yueling Hao; Qing Shi; Anita B Hjelmeland; Mark W Dewhirst; Darell D Bigner; Jeremy N Rich
Journal: Nature Date: 2006-10-18 Impact factor: 49.962

6. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma.

Authors: Keith L Ligon; Emmanuelle Huillard; Shwetal Mehta; Santosh Kesari; Hongye Liu; John A Alberta; Robert M Bachoo; Michael Kane; David N Louis; Ronald A Depinho; David J Anderson; Charles D Stiles; David H Rowitch
Journal: Neuron Date: 2007-02-15 Impact factor: 17.173

7. Phase II trial of bevacizumab and irinotecan in recurrent malignant glioma.

Authors: James J Vredenburgh; Annick Desjardins; James E Herndon; Jeannette M Dowell; David A Reardon; Jennifer A Quinn; Jeremy N Rich; Sith Sathornsumetee; Sridharan Gururangan; Melissa Wagner; Darell D Bigner; Allan H Friedman; Henry S Friedman
Journal: Clin Cancer Res Date: 2007-02-15 Impact factor: 12.531

8. Oct4 is expressed in human gliomas and promotes colony formation in glioma cells.

Authors: Zhanhui Du; Deyong Jia; Shangming Liu; Fuwu Wang; Gang Li; Yanmin Zhang; Xinmin Cao; Eng-Ang Ling; Aijun Hao
Journal: Glia Date: 2009-05 Impact factor: 7.452

9. Cyclopamine-mediated hedgehog pathway inhibition depletes stem-like cancer cells in glioblastoma.

Authors: Eli E Bar; Aneeka Chaudhry; Alex Lin; Xing Fan; Karisa Schreck; William Matsui; Sara Piccirillo; Angelo L Vescovi; Francesco DiMeco; Alessandro Olivi; Charles G Eberhart
Journal: Stem Cells Date: 2007-07-12 Impact factor: 6.277

10. Bmi1 and cell of origin determinants of brain tumor phenotype.

Authors: Peter Dirks
Journal: Cancer Cell Date: 2007-10 Impact factor: 31.743

47 in total

1. Stem-like tumor-initiating cells isolated from IL13Rα2 expressing gliomas are targeted and killed by IL13-zetakine-redirected T Cells.

Authors: Christine E Brown; Renate Starr; Brenda Aguilar; Andrew F Shami; Catalina Martinez; Massimo D'Apuzzo; Michael E Barish; Stephen J Forman; Michael C Jensen
Journal: Clin Cancer Res Date: 2012-03-08 Impact factor: 12.531

Review 2. Unique biology of gliomas: challenges and opportunities.

Authors: Stacey Watkins; Harald Sontheimer
Journal: Trends Neurosci Date: 2012-06-08 Impact factor: 13.837

Review 3. Targeted therapy for malignant glioma patients: lessons learned and the road ahead.

Authors: Tiffany T Huang; Shawn M Sarkaria; Timothy F Cloughesy; Paul S Mischel
Journal: Neurotherapeutics Date: 2009-07 Impact factor: 7.620

Review 4. MicroRNAs as regulators of neural stem cell-related pathways in glioblastoma multiforme.

Authors: Pilar González-Gómez; Pilar Sánchez; Helena Mira
Journal: Mol Neurobiol Date: 2011-07-05 Impact factor: 5.590

Review 5. NF-kappaB and STAT3 signaling in glioma: targets for future therapies.

Authors: George P Atkinson; Susan E Nozell; Etty Tika N Benveniste
Journal: Expert Rev Neurother Date: 2010-04 Impact factor: 4.618

Review 6. Cancer stem cells and radioresistance.

Authors: Kiera Rycaj; Dean G Tang
Journal: Int J Radiat Biol Date: 2014-03-07 Impact factor: 2.694

Review 7. The bright and the dark sides of DNA repair in stem cells.

Authors: Guido Frosina
Journal: J Biomed Biotechnol Date: 2010-04-08

Review 8. Brain tumor stem cells as therapeutic targets in models of glioma.

Authors: Dan Richard Laks; Koppany Visnyei; Harley Ian Kornblum
Journal: Yonsei Med J Date: 2010-09 Impact factor: 2.759

9. Diffuse Intrinsic Pontine Gliomas Exhibit Cell Biological and Molecular Signatures of Fetal Hindbrain-Derived Neural Progenitor Cells.

Authors: Yu Sun; Cheng Xu; Changcun Pan; Xin Chen; Yibo Geng; Yuliang Wu; Peng Zhang; Wenhao Wu; Yu Wang; Deling Li; Zhen Wu; Junting Zhang; Qiaoran Xi; Liwei Zhang
Journal: Neurosci Bull Date: 2019-01-03 Impact factor: 5.203

10. Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma.

Authors: Carlos Rodrigo Gil del Alcazar; Molly Catherine Hardebeck; Bipasha Mukherjee; Nozomi Tomimatsu; Xiaohuan Gao; Jingsheng Yan; Xian-Jin Xie; Robert Bachoo; Li Li; Amyn A Habib; Sandeep Burma
Journal: Clin Cancer Res Date: 2013-12-23 Impact factor: 12.531