| Literature DB >> 17296553 |
Keith L Ligon1, Emmanuelle Huillard, Shwetal Mehta, Santosh Kesari, Hongye Liu, John A Alberta, Robert M Bachoo, Michael Kane, David N Louis, Ronald A Depinho, David J Anderson, Charles D Stiles, David H Rowitch.
Abstract
Recent studies have identified stem cells in brain cancer. However, their relationship to normal CNS progenitors, including dependence on common lineage-restricted pathways, is unclear. We observe expression of the CNS-restricted transcription factor, OLIG2, in human glioma stem and progenitor cells reminiscent of type C transit-amplifying cells in germinal zones of the adult brain. Olig2 function is required for proliferation of neural progenitors and for glioma formation in a genetically relevant murine model. Moreover, we show p21(WAF1/CIP1), a tumor suppressor and inhibitor of stem cell proliferation, is directly repressed by OLIG2 in neural progenitors and gliomas. Our findings identify an Olig2-regulated lineage-restricted pathway critical for proliferation of normal and tumorigenic CNS stem cells.Entities:
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Year: 2007 PMID： 17296553 PMCID： PMC1810344 DOI： 10.1016/j.neuron.2007.01.009
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173