| Literature DB >> 17222792 |
Tracy T Batchelor1, A Gregory Sorensen, Emmanuelle di Tomaso, Wei-Ting Zhang, Dan G Duda, Kenneth S Cohen, Kevin R Kozak, Daniel P Cahill, Poe-Jou Chen, Mingwang Zhu, Marek Ancukiewicz, Maciej M Mrugala, Scott Plotkin, Jan Drappatz, David N Louis, Percy Ivy, David T Scadden, Thomas Benner, Jay S Loeffler, Patrick Y Wen, Rakesh K Jain.
Abstract
Using MRI techniques, we show here that normalization of tumor vessels in recurrent glioblastoma patients by daily administration of AZD2171-an oral tyrosine kinase inhibitor of VEGF receptors-has rapid onset, is prolonged but reversible, and has the significant clinical benefit of alleviating edema. Reversal of normalization began by 28 days, though some features persisted for as long as four months. Basic FGF, SDF1alpha, and viable circulating endothelial cells (CECs) increased when tumors escaped treatment, and circulating progenitor cells (CPCs) increased when tumors progressed after drug interruption. Our study provides insight into different mechanisms of action of this class of drugs in recurrent glioblastoma patients and suggests that the timing of combination therapy may be critical for optimizing activity against this tumor.Entities:
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Year: 2007 PMID： 17222792 PMCID： PMC2748664 DOI： 10.1016/j.ccr.2006.11.021
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743