Literature DB >> 24527669

Cancer stem cells and radioresistance.

Kiera Rycaj1, Dean G Tang.   

Abstract

PURPOSE: Radiation therapy has made significant contributions to cancer treatment. However, despite continuous improvements, tumor recurrence and therapy resistance still occur in a high proportion of patients. One underlying reason for this radioresistance might be attributable to the presence of cancer stem cells (CSC). The purpose of this review is to discuss CSC-specific mechanisms that confer radiation resistance.
CONCLUSIONS: We focus our discussions on breast cancer and glioblastoma multiforme (GBM) and conclude that both CSC-intrinsic and CSC-extrinsic factors as well as adaptive responses in CSC caused by irradiation and microenvironmental changes all make contributions to CSC-mediated radioresistance. Our discussions emphasize CSC as novel therapeutic targets in order to potentiate radiotherapy efficacy.

Entities:  

Keywords:  Cancer stem cells; hypoxia; microenvironment; plasticity; radiation therapy; radioresistance; radiosensitivity

Mesh：

Year:  2014        PMID： 24527669      PMCID： PMC4341971          DOI： 10.3109/09553002.2014.892227

Source DB:  PubMed          Journal:  Int J Radiat Biol        ISSN： 0955-3002            Impact factor:   2.694


  59 in total

1.  RESPONSE: Re: Brain and Other Central Nervous System Cancers: Recent Trends in Incidence and Mortality.

Authors: 
Journal:  J Natl Cancer Inst       Date:  1999-12-01       Impact factor: 13.506

Review 2.  Is there a common mechanism underlying genomic instability, bystander effects and other nontargeted effects of exposure to ionizing radiation?

Authors:  William F Morgan
Journal:  Oncogene       Date:  2003-10-13       Impact factor: 9.867

Review 3.  Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology.

Authors:  Douglas R Spitz; Edouard I Azzam; Jian Jian Li; David Gius
Journal:  Cancer Metastasis Rev       Date:  2004 Aug-Dec       Impact factor: 9.264

4.  A role for homologous recombination and abnormal cell-cycle progression in radioresistance of glioma-initiating cells.

Authors:  Yi Chieh Lim; Tara L Roberts; Bryan W Day; Angus Harding; Sergei Kozlov; Amanda W Kijas; Kathleen S Ensbey; David G Walker; Martin F Lavin
Journal:  Mol Cancer Ther       Date:  2012-07-06       Impact factor: 6.261

Review 5.  Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials.

Authors:  M Clarke; R Collins; S Darby; C Davies; P Elphinstone; V Evans; J Godwin; R Gray; C Hicks; S James; E MacKinnon; P McGale; T McHugh; R Peto; C Taylor; Y Wang
Journal:  Lancet       Date:  2005-12-17       Impact factor: 79.321

Review 6.  Cancer stem cells: mirage or reality?

Authors:  Piyush B Gupta; Christine L Chaffer; Robert A Weinberg
Journal:  Nat Med       Date:  2009-09-04       Impact factor: 53.440

7.  Selective targeting of radiation-resistant tumor-initiating cells.

Authors:  Mei Zhang; Rachel L Atkinson; Jeffrey M Rosen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-03       Impact factor: 11.205

8.  BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.

Authors:  Sabrina Facchino; Mohamed Abdouh; Wassim Chatoo; Gilbert Bernier
Journal:  J Neurosci       Date:  2010-07-28       Impact factor: 6.167

9.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
View more
  88 in total

1.  Oxidative stress induces senescence in breast cancer stem cells.

Authors:  Guangxian Zhong; Shenghui Qin; Danyelle Townsend; Bradley A Schulte; Kenneth D Tew; Gavin Y Wang
Journal:  Biochem Biophys Res Commun       Date:  2019-05-17       Impact factor: 3.575

2.  Molecularly targeted radiosensitization chances towards gene aberration-due organ confined/regionally advanced prostate cancer radioresistance.

Authors:  C Alberti
Journal:  G Chir       Date:  2015 May-Jun

Review 3.  The mechanisms of radioresistance in esophageal squamous cell carcinoma and current strategies in radiosensitivity.

Authors:  Guang-Zong Chen; Hong-Cheng Zhu; Wang-Shu Dai; Xiao-Ning Zeng; Jin-Hua Luo; Xin-Chen Sun
Journal:  J Thorac Dis       Date:  2017-03       Impact factor: 2.895

4.  CD133 Expression Predicts Relapse in Patients With Locally Advanced Rectal Cancer Treated With Neoadjuvant Chemotherapy.

Authors:  Haruka Oi; Takashi Okuyama; Shunya Miyazaki; Yuko Ono; Masatoshi Oya
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

5.  Radiation induces an inflammatory response that results in STAT3-dependent changes in cellular plasticity and radioresistance of breast cancer stem-like cells.

Authors:  Kimberly M Arnold; Lynn M Opdenaker; Nicole J Flynn; Daniel Kwesi Appeah; Jennifer Sims-Mourtada
Journal:  Int J Radiat Biol       Date:  2020-01-06       Impact factor: 2.694

6.  A phase I/II trial of 5-fraction stereotactic radiosurgery with 5-mm margins with concurrent temozolomide in newly diagnosed glioblastoma: primary outcomes.

Authors:  Melissa Azoulay; Steven D Chang; Iris C Gibbs; Steven L Hancock; Erqi L Pollom; Griffith R Harsh; John R Adler; Ciara Harraher; Gordon Li; Melanie Hayden Gephart; Seema Nagpal; Reena P Thomas; Lawrence D Recht; Lisa R Jacobs; Leslie A Modlin; Jacob Wynne; Kira Seiger; Dylann Fujimoto; Melissa Usoz; Rie von Eyben; Clara Y H Choi; Scott G Soltys
Journal:  Neuro Oncol       Date:  2020-08-17       Impact factor: 12.300

7.  Prognostic value of periostin in early-stage breast cancer treated with conserving surgery and radiotherapy.

Authors:  Changyou Li; Jing Xu; Qi Wang; Shaoqing Geng; Zheng Yan; Jin You; Zhenfeng Li; Xiao Zou
Journal:  Oncol Lett       Date:  2018-03-21       Impact factor: 2.967

Review 8.  Cancer stem cells: Regulation programs, immunological properties and immunotherapy.

Authors:  Dingxiao Zhang; Dean G Tang; Kiera Rycaj
Journal:  Semin Cancer Biol       Date:  2018-05-09       Impact factor: 15.707

9.  Reversal effect of GnT-V on the radioresistance of human nasopharyngeal carcinoma cells by alteration β1, 6-GlcNAc branched N-glycans.

Authors:  Jun-Bo Wu; Li Shen; Li Qiu; Qi-Wen Duan; Zhi-Guo Luo; Xiao-Xia Dong
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

10.  Autophagy Inhibition to Increase Radiosensitization in Breast Cancer.

Authors:  Diana Hwang Liang; Randa El-Zein; Bhuvanesh Dave
Journal:  J Nucl Med Radiat Ther       Date:  2015-09-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.