Literature DB >> 19280292

In vitro antifungal combination effects of micafungin with fluconazole, voriconazole, amphotericin B, and flucytosine against clinical isolates of Candida species.

Isao Nishi1, Atsuko Sunada, Masahiro Toyokawa, Seishi Asari, Yoshinori Iwatani.   

Abstract

Micafungin (MCFG) is an echinocandin antifungal agent that exhibits potent activity against most species of Candida and Aspergillus. We investigated the in vitro antifungal combination effects of MCFG with four other antifungal agents - fluconazole (FLCZ), voriconazole (VRCZ), amphotericin B, and flucytosine - against clinical isolates of 54 Candida spp. by checkerboard analysis. The synergistic antifungal effects of MCFG-FLCZ and MCFG-VRCZ were 11% and 15%, respectively, and the latter displayed a synergistic activity of 63% against Candida glabrata. Antagonism was not observed in any of the combinations tested.

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Year:  2009        PMID： 19280292     DOI： 10.1007/s10156-008-0653-9

Source DB:  PubMed          Journal:  J Infect Chemother        ISSN： 1341-321X            Impact factor:   2.211


  8 in total

1.  Multilaboratory testing of two-drug combinations of antifungals against Candida albicans, Candida glabrata, and Candida parapsilosis.

Authors:  Vishnu Chaturvedi; Rama Ramani; David Andes; Daniel J Diekema; Michael A Pfaller; Mahmoud A Ghannoum; Cindy Knapp; Shawn R Lockhart; Luis Ostrosky-Zeichner; Thomas J Walsh; Karen Marchillo; Shawn Messer; Amanda R Welshenbaugh; Cara Bastulli; Noreen Iqbal; Victor L Paetznick; Jose Rodriguez; Tin Sein
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

2.  Azole-synergistic anti-candidal activity of altenusin, a biphenyl metabolite of the endophytic fungus Alternaria alternata isolated from Terminalia chebula Retz.

Authors:  Jatuporn Phaopongthai; Suthep Wiyakrutta; Duangdeun Meksuriyen; Nongluksna Sriubolmas; Khanit Suwanborirux
Journal:  J Microbiol       Date:  2013-12-19       Impact factor: 3.422

3.  Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.

Authors:  Willmen Youngsaye; Chris Dockendorff; Benjamin Vincent; Cathy L Hartland; Joshua A Bittker; Sivaraman Dandapani; Michelle Palmer; Luke Whitesell; Susan Lindquist; Stuart L Schreiber; Benito Munoz
Journal:  Bioorg Med Chem Lett       Date:  2012-02-22       Impact factor: 2.823

4.  Novel method for evaluating in vitro activity of anidulafungin in combination with amphotericin B or azoles.

Authors:  R Teixeira-Santos; R Rocha; A Moreira-Rosário; M Monteiro-Soares; E Cantón; A G Rodrigues; C Pina-Vaz
Journal:  J Clin Microbiol       Date:  2012-06-12       Impact factor: 5.948

5.  Multicenter prospective observational study of fungal keratitis in Japan: analyses of in vitro susceptibility tests for combinations of drugs.

Authors:  Keigo Kimura; Yoshitsugu Inoue; Seishi Asari; Atsuko Sunada; Yuichi Ohashi; Yoshikazu Shimomura; Chie Sotozono; Hiroshi Hatano; Masahiko Fukuda; Hiroshi Eguchi; Kaoru Araki-Sasaki; Takashi Suzuki; Saichi Hoshi; Toru Tobe; Takashi Yaguchi; Koichi Makimura
Journal:  Jpn J Ophthalmol       Date:  2022-03-29       Impact factor: 2.447

6.  Potent Synergy between Spirocyclic Pyrrolidinoindolinones and Fluconazole against Candida albicans.

Authors:  Ilandari Dewage Udara Anulal Premachandra; Kevin A Scott; Chengtian Shen; Fuqiang Wang; Shelley Lane; Haoping Liu; David L Van Vranken
Journal:  ChemMedChem       Date:  2015-08-12       Impact factor: 3.466

7.  Bioassay for Determining Voriconazole Serum Levels in Patients Receiving Combination Therapy with Echinocandins.

Authors:  Maria Siopi; Efthymios Neroutsos; Kalliopi Zisaki; Maria Gamaletsou; Maria Pirounaki; Panagiotis Tsirigotis; Nikolaos Sipsas; Aristides Dokoumetzidis; Evgenios Goussetis; Loukia Zerva; Georgia Valsami; Joseph Meletiadis
Journal:  Antimicrob Agents Chemother       Date:  2015-10-26       Impact factor: 5.191

Review 8.  Isavuconazole and Liposomal Amphotericin B as Successful Combination Therapy of Refractory Invasive Candidiasis in a Liver Transplant Recipient: A Case Report and Literature Review.

Authors:  Georgios Odysseos; Ulrich Mayr; Gabor Bozsaki; Christian Seidensticker; Ursula Ehmer; Roland M Schmid; Tobias Lahmer; Veronika Dill
Journal:  Mycopathologia       Date:  2021-10-31       Impact factor: 2.574
  8 in total

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