| Literature DB >> 26503649 |
Maria Siopi1, Efthymios Neroutsos2, Kalliopi Zisaki3, Maria Gamaletsou4, Maria Pirounaki5, Panagiotis Tsirigotis6, Nikolaos Sipsas4, Aristides Dokoumetzidis2, Evgenios Goussetis3, Loukia Zerva1, Georgia Valsami2, Joseph Meletiadis7.
Abstract
Voriconazole levels were determined with high-performance liquid chromatography (HPLC) and a microbiological agar diffusion assay using a Candida parapsilosis isolate in 103 serum samples from an HPLC-tested external quality control program (n = 39), 21 patients receiving voriconazole monotherapy (n = 39), and 7 patients receiving combination therapy (n = 25). The results of the bioassay were correlated with the results obtained from the external quality control program samples and with the HPLC results in sera from patients on voriconazole monotherapy and on combination therapy with an echinocandin (Spearman's rank correlation coefficient [rs], > 0.93; mean ± standard error of the mean [SEM] % difference, <12% ± 3.8%).Entities:
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Year: 2015 PMID: 26503649 PMCID: PMC4704192 DOI: 10.1128/AAC.01688-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191